Results 251 to 260 of about 279,832 (297)

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Bone morphogenetic protein 10 serves as a biomarker and a potential therapeutic target for endothelial dysfunction in endotoxin-induced acute lung injury. [PDF]

J Transl Med
Yu WK, Chen WC, Shen HC, Sun CY, Yu HJ, Su VY, Yang KY.   +6 more
europepmc   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation. [PDF]

World J Gastroenterol
Zhang MX, Wu C, Feng XX, Tian W, Zhao NH, Lu PP, Ding Q, Liu M.   +7 more
europepmc   +1 more source

Theranostic Toolbox for Neutrophil Functionalization

Advanced Science, EarlyView.
Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain, Kay‐Matthias Thomy, Anika Maria Prinz, Bodo Steckel, Shiwa Kadir, Alexandra Röhs, Jonas Schmitz, Claudia Dohle, Matthias Karg, Maria Grandoch, Ulrich Flögel, Sebastian Temme   +11 more
wiley   +1 more source

Gut microbiome dysbiosis accelerates osteoarthritis progression by inducing IFP-SM inflammation in "double-hit" mice. [PDF]

Arthritis Res Ther
Liu S, Xu H, Liu L, Ma W, Fan H, Liu F, Wei Z, Hao J, Zheng Z, Zhao L, Yang B, Wu Z.   +11 more
europepmc   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

Correction: Plumbagin protects mice from lethal Sepsis by modulating immunometabolism upstream of PKM2. [PDF]

Mol Med
Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, Cao L, Tang D.   +7 more
europepmc   +1 more source

Effect of Lipopolysaccharide (LPS) on Oxidative Stress and Apoptosis in Immune Tissues from <i>Schizothorax prenanti</i>. [PDF]

Animals (Basel)
Huang J, Jiang W, Ma H, Zhang H, Zhao H, Wang Q, Zhang J.   +6 more
europepmc   +1 more source

Effects of lipopolysaccharide administration on thymus damage, antioxidant capacity and immune function in weaned piglets. [PDF]

J Vet Res
Bai L, Jiang Y, Li X, Yu W, Zhu W, Zhao G, Yang T, Zhou Y, Li J, Li Y.   +9 more
europepmc   +1 more source