Results 41 to 50 of about 519,050 (337)

Protective effects of Dioscin against sepsis‐induced cardiomyopathy via regulation of toll‐like receptor 4/MyD88/p65 signal pathway

Immunity, Inflammation and Disease
Background Dioscin has many pharmacological effects; however, its role in sepsis‐induced cardiomyopathy (SIC) is unknown. Accordingly, we concentrate on elucidating the mechanism of Dioscin in SIC rat model.
Meng Zhang, Deyuan Zhi, Pei Liu, Yajun Wang, Meili Duan   +4 more
doaj   +1 more source

Chlorogenic Acid Intravesical Therapy Changes Acute Voiding Behavior of Systemic Lipopolysaccharide Inflammation-Induced Cystitis Bladder in Mice

Toxics
This study explores the potential efficacy of chlorogenic acid (CGA) in mitigating lipopolysaccharide (LPS)-induced cystitis in a mice model. C57BL/6J mice were divided into four groups: normal control (NC), LPS, LPS + low CGA, and LPS + high CGA ...
Chung-Hsin Yeh, Chellappan Praveen Rajneesh, Chun-Hou Liao, Wen-Chen You, Kuo-Chiang Chen, Yi-No Wu, Han-Sun Chiang   +6 more
doaj   +1 more source

Xanthine Derivative KMUP-1 Attenuates Experimental Periodontitis by Reducing Osteoclast Differentiation and Inflammation

Frontiers in Pharmacology, 2022
Periodontitis is an inflammatory disease of gum that may predispose to serious systemic complications such as diabetes and cardiovascular diseases. Activation of macrophages and osteoclasts around periodontal tissue can accelerate gum inflammation.
Cheng-Hsiang Kuo, Ban-Hua Zhang, Shang-En Huang, Jong-Hau Hsu, Jong-Hau Hsu, Jong-Hau Hsu, Yan-Hsiung Wang, Yan-Hsiung Wang, Yan-Hsiung Wang, Yan-Hsiung Wang, Thi Tuyet Ngan Nguyen, Chao-Han Lai, Chao-Han Lai, Chao-Han Lai, Chao-Han Lai, Jwu-Lai Yeh, Jwu-Lai Yeh, Jwu-Lai Yeh   +17 more
doaj   +1 more source

Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide [PDF]

, 2013
Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.
Ali, Irshad, Audi, Said H., Densmore, John C., Husnain, Fouad, Jacobs, Elizabeth R., Konduri, G. Ganesh, Medhora, Meetha, Nanchal, Rahul   +7 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Ethyl Acetate Extract of Caulerpa microphysa Promotes Collagen Homeostasis and Inhibits Inflammation in the Skin

Current Issues in Molecular Biology
Inflammation and collagen-degrading enzymes’ overexpression promote collagen decomposition, which affects the structural integrity of the extracellular matrix. The polysaccharide and peptide extracts of the green alga Caulerpa microphysa (C.
Kuo-Yun Lu, Li-Ching Cheng, Zheng-Ci Hung, Ze-Ying Chen, Chuang-Wei Wang, Hsin-Han Hou   +5 more
doaj   +1 more source

Lipid A-Mediated Bacterial–Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants

Molecules, 2021
Gram-negative bacterial cell surface component lipopolysaccharide (LPS) and its active principle, lipid A, exhibit immunostimulatory effects and have the potential to act as adjuvants.
Atsushi Shimoyama, Koichi Fukase
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genetic line-specific immune profiles and immunometabolic responses to intramuscular lipopolysaccharide injection

Frontiers in Immunology
Previous research has investigated highly inbred chicken genetic lines from a metabolic, immune response, genetic profile, and immune trait standpoint, including response to lipopolysaccharide (LPS).
Kayla M. Elmore, Susan J. Lamont, Elizabeth A. Bobeck   +2 more
doaj   +1 more source

LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

Pharmaceuticals, 2021
High mobility group box (HMGB)1 action contributes to late phases of sepsis, but the effects of increased endogenous plasma HMGB1 levels on brain cells during inflammation are unclear.
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Rüdiger Gerstberger, Marita Meurer, Maren von Köckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel   +11 more
doaj   +1 more source