Results 1 to 10 of about 304,856 (335)

Lipopolysaccharide Endotoxins [PDF]

Annual Review of Biochemistry, 2002
▪ Abstract  Bacterial lipopolysaccharides (LPS) typically consist of a hydrophobic domain known as lipid A (or endotoxin), a nonrepeating “core” oligosaccharide, and a distal polysaccharide (or O-antigen). Recent genomic data have facilitated study of LPS assembly in diverse Gram-negative bacteria, many of which are human or plant pathogens, and have ...
Christian R H, Raetz, Chris, Whitfield
openaire   +3 more sources

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

Journal of Gastrointestinal Surgery, 2021
Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty (NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting 10–24% of the general population and approximately 70% of obese patients, it carries a large economic burden ...
Lingxuan An, U. Wirth, D. Koch, M. Schirren, M. Drefs, D. Koliogiannis, H. Niess, J. Andrassy, M. Guba, A. Bazhin, J. Werner, F. Kühn   +11 more
semanticscholar   +1 more source

Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer

Journal of Gastrointestinal Surgery, 2023
Inflammation is known to be an essential driver of various types of cancer. An increasing number of studies have suggested that the occurrence and development of colorectal cancer (CRC) are linked to the inflammatory microenvironment of the intestine ...
Qiang Li, Viktor von Ehrlich-Treuenstätt, Josefine Schardey, U. Wirth, P. Zimmermann, J. Andrassy, A. Bazhin, J. Werner, Florian Kühn   +8 more
semanticscholar   +1 more source

Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications

Translational Neurodegeneration, 2021
Alzheimer’s disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline. Failures in the development of therapeutics targeting amyloid-β (Aβ) and tau, principal proteins inducing ...
Hyeon Soo Kim, Sujin Kim, Soo Jung Shin, Yong Ho Park, Yunkwon Nam, C. Kim, Kang won Lee, Sung-Min Kim, I. Jung, Hyun-Duk Yang, Yeong-Min Park, M. Moon   +11 more
semanticscholar   +1 more source

Role of Endogenous Lipopolysaccharides in Neurological Disorders

Cells, 2022
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-negative bacteria. A growing body of evidence reveals that alterations in the bacterial composition of the intestinal microbiota (gut dysbiosis) disrupt host immune ...
Manjunath Kalyan, Ahmed Hediyal Tousif, S. Sonali, C. Vichitra, Tuladhar Sunanda, Sankar Simla Praveenraj, Bipul Ray, V. Gorantla, W. Rungratanawanich, A. Mahalakshmi, M. W. Qoronfleh, T. Monaghan, B. Song, M. Essa, Saravanabau Chidambaram   +14 more
semanticscholar   +1 more source

Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner

Gut microbes, 2020
Patients presenting with Inflammatory bowel disease have been shown to exhibit an altered microbiome in both Crohn’s disease and Ulcerative colitis. This shift in the microbial content led us to question whether several of these microbes are important in
M. Stephens, P. von der Weid
semanticscholar   +1 more source

Site-Specific Conditions Change the Response of Bacterial Producers of Soil Structure-Stabilizing Agents Such as Exopolysaccarides and Lipopolysaccarides to Tillage Intensity [PDF]

, 2020
Agro-ecosystems experience huge losses of land every year due to soil erosion induced by poor agricultural practices such as intensive tillage. Erosion can be minimized by the presence of stable soil aggregates, the formation of which can be promoted by ...
Cania, Barbara, Fliessbach, Andreas, Krauss, Maike, Mihelič, Rok, Mäder, Paul, Schloter, Michael, Schulz, Stefanie, Suhadolc, Marjetka, Szumelda, Anna, Vestergaard, Gisle   +9 more
core   +1 more source

Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. [PDF]

, 1978
The effect of the common lipid moiety of bacterial LPS on secretion from washed human platelets has been studied. The lipid A-rich LPS of S. minnesota R595 and a lipid A preparation both potentiated platelet serotonin secretion in response to IgG ...
Ginsberg, MH, Henson, PM
core   +1 more source

Ruminal acidosis, bacterial changes, and lipopolysaccharides.

Journal of Animal Science, 2020
Acute and subacute ruminal acidosis (SARA) are common nutritional problems in both beef and dairy cattle. Therefore, the objective of this review is to describe how ruminal Gram-negative bacteria could contribute to the pathogenesis of ruminal acidosis ...
H. Monteiro, A. Faciola
semanticscholar   +1 more source

Lipopolysaccharide antagonists

Immunology Today, 1992
Bacterial lipopolysaccharide (LPS) is a potent and pleiotropic stimulus of immune cells. LPS has important clinical relevance because it has a direct role in the pathogenesis of Gram-negative bacterial infection. The lipid A moiety of LPS is responsible for the toxic effects of LPS.
W A, Lynn, D T, Golenbock
openaire   +2 more sources