Results 101 to 110 of about 864,255 (364)
Debiased Inference on Heterogeneous Quantile Treatment Effects with Regression Rank-Scores [PDF]
arXiv, 2021 Understanding treatment effect heterogeneity is vital to many scientific fields because the same treatment may affect different individuals differently. Quantile regression provides a natural framework for modeling such heterogeneity. We propose a new method for inference on heterogeneous quantile treatment effects in the presence of high-dimensional ...
arxiv
Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects
Advanced Functional Materials, EarlyView.Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu +6 more
wiley +1 more source
Bacterial expression and site-directed mutagenesis of a functional recombinant apolipoprotein.
Journal of Lipid Research, 1995 To facilitate structure-function studies of Manduca sexta apolipophorin III (apoLp-III), its nucleotide coding sequence was cloned from a fat body cDNA library by in vitro DNA amplification.
R O Ryan +6 more
doaj
Pharmacology Research & Perspectives, 2020 Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholesterol‐rich lipoprotein ...
Marcelo J. A. Amar +8 more
doaj +1 more source
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Journal of Lipid Research, 1996 Mutations in the gene for the low density lipoprotein (LDL) receptor have been identified in 15 patients with homozygous familial hypercholesterolemia (FH).
J C Webb +6 more
doaj
Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results. [PDF]
, 2018 Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements.
Canaud, Bernard +11 more
core +3 more sources
Stability of discoidal high-density lipoprotein particles [PDF]
arXiv, 2013 Motivated by experimental and numerical studies revealing that discoidal high-density lipoprotein (HDL) particles may adopt flat elliptical and nonplanar saddle-like configurations, it is hypothesized that these might represent stabilized configurations of initially unstable flat circular particles. A variational description is developed to explore the
arxiv
Lipoprotein remnants: to be or not to be [PDF]
European Heart Journal, 2021 Angela Pirillo, Alberico Luigi Catapano
openaire +2 more sources