Results 131 to 140 of about 864,255 (364)

Nonimmunochemical quantitation of mammalian apolipoprotein A-I in whole serum or plasma by nonreducing gel electrophoresis.

open access: yesJournal of Lipid Research, 1989
A rapid and convenient method for the quantitation of mammalian apoA-I has been developed. The method involves nonreducing sodium dodecyl sulfate gel electrophoresis and Coomassie blue staining, and takes advantage of the relative abundance of apoA-I in ...
D S France   +7 more
doaj  

Spirochetal Lipoproteins and Immune Evasion. [PDF]

open access: yes, 2017
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani   +2 more
core   +1 more source

Two Robust Tools for Inference about Causal Effects with Invalid Instruments [PDF]

open access: yesarXiv, 2020
Instrumental variables have been widely used to estimate the causal effect of a treatment on an outcome. Existing confidence intervals for causal effects based on instrumental variables assume that all of the putative instrumental variables are valid; a valid instrumental variable is a variable that affects the outcome only by affecting the treatment ...
arxiv  

Geniposidic Acid Targeting FXR “S332 and H447” Mediated Conformational Change to Upregulate CYPs and miR‐19a‐3p to Ameliorate Drug‐Induced Liver Injury

open access: yesAdvanced Science, EarlyView.
Drug abuse exacerbates cholesterol and bile acids burden, causing liver injury. Geniposidic acid targets FXR Ser332 and His447, together with SRC2‐3 recruitment and activated FXR nuclear translocation. Geniposidic acid‐activated FXR can upregulate CYPs to accelerate bile acids clearance and activate miR‐19a‐3p to suppress LXR‐mediated cholesterol ...
Minqi Fan   +8 more
wiley   +1 more source

Extracellular Matrix Targeted MRI Probes

open access: yesAnalysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Gadolinium based MRI probes targeted to ECM components, either proteins or enzymes, hold promise for accurate molecular characterization and staging of fibrotic diseases in vivo. Non‐covalent binding probes (1), reactive probes (2), and enzyme‐responsive probes (3) are discussed.
Giuseppe Digilio   +3 more
wiley   +1 more source

An immunochemical marker of low density lipoprotein oxidation.

open access: yesJournal of Lipid Research, 1989
Using monoclonal antibodies against apolipoprotein B (apoB) we studied changes in apoB immunoreactivity during copper ion-mediated oxidation of human low density lipoprotein (LDL).
Z Zawadzki, R W Milne, Y L Marcel
doaj  

A Latent Mixture Model for Heterogeneous Causal Mechanisms in Mendelian Randomization [PDF]

open access: yesarXiv, 2020
Mendelian Randomization (MR) is a popular method in epidemiology and genetics that uses genetic variation as instrumental variables for causal inference. Existing MR methods usually assume most genetic variants are valid instrumental variables that identify a common causal effect.
arxiv  

Role of oxidized low density lipoprotein in atherogenesis.

open access: yesJournal of Clinical Investigation, 1991
Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process ...
J. Witztum, D. Steinberg
semanticscholar   +1 more source

Nanotherapy for Neural Retinal Regeneration

open access: yesAdvanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu   +11 more
wiley   +1 more source

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