Results 161 to 170 of about 840,133 (341)

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

Advanced Science, EarlyView.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Harold Bae, Catherine E Costello, Matthew Au, Lingyi Lynn Deng, Mengze Li, Qingyan Xiang, Heeju Noh, Lance Pflieger, Cory Funk, Noa Rappaport, Marianne Nygaard, Meghan I Short, Michael Brent, Stefano Monti, Stacy L Andersen, Thomas T Perls   +20 more
wiley   +1 more source

Low-density lipoprotein cholesterol to apolipoprotein B ratio is associated with all-cause mortality and cardiovascular events among incident peritoneal dialysis patients [PDF]

, 2022
Xiaojiang Zhan, Chuanfei Zeng, Qing Zhan, Xiqi Dong, Yanbing Chen   +4 more
openalex   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Serum lipid profiles in acute myocardial infarction patients in Gorgan [PDF]

, 2012
Acute myocardial infarction is one of the important reasons of death and unhealthiness in the world. The present study was undertaken to investigate the changes in serum lipids and lipoproteins in patients with acute myocardial infarction. This study was
Marjani, A., Shirafkan, A., Zaker, F.
core  

Structural analysis of Borrelia burgdorferi periplasmic lipoprotein BB0365 involved in Lyme disease infection [PDF]

, 2019
Kalvis Brangulis, Ināra Akopjana, Ivars Petrovskis, Andris Kazāks, Atis Je̅kabsons, Kristaps Jaudzems, Artūrs Vīksna, Māris Bērtiņš, Kaspars Tārs   +8 more
openalex   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Linear and nonlinear analyses of the association between low–density lipoprotein cholesterol and diabetes: The spurious U–curve in observational study

, 2022
Yujia Ma, Zechen Zhou, Xiaoyi Li, Kexin Ding, Han Xiao, Yiqun Wu, Tao Wu, Dafang Chen   +7 more
openalex   +1 more source

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

Supramolecular Assembly of High-Density Lipoprotein Mimetic Nanoparticles Using Lipid-Conjugated Core Scaffolds

, 2019
Stephen E. Henrich, Bong Jin Hong, Jonathan S. Rink, SonBinh T. Nguyen, C. Shad Thaxton   +4 more
openalex   +2 more sources

Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study [PDF]

, 2006
G.A.M. van den Bos, M C Poortvliet, P Scheffer, Joost Dekker, Marga C. Ocké, Giel Nijpels, Coen D.A. Stehouwer, L.M. Bouter, Tom Teerlink, Robert J. Heine   +9 more
openalex   +1 more source