Results 91 to 100 of about 428,553 (167)

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Let's be CLEAR: Cath Lab Evaluation of Atherosclerotic Risk is a disease modifying opportunity. [PDF]

Br J Cardiol
Cunneen B, O'Callaghan D, O'Callaghan C, O'Neill F, Loo B, Wheen P, Moore D, Mulcahy D, Armstrong R, Maher V.   +9 more
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management. [PDF]

MedComm (2020)
Qi S, Chen W, Chen K, Yang S, Wang S, Ni T, Xu D, Mao E, Chen E, Chen Y.   +9 more
europepmc   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Exploring the role of gut microbiota in coronary atherosclerosis through lipoprotein-mediated cholesterol transport and distribution: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Liu X, Shen K, Zhu F, Cheng C, Yu H.
europepmc   +1 more source

Association and Age Heterogeneity of Systemic Metabolomic Signatures With Age-Related Cataract: A Mendelian Randomization and Heterogeneity Analysis. [PDF]

Transl Vis Sci Technol
Liu Z, Lu A, He S, Wang Y, Su G, Yang P.
europepmc   +1 more source

Clinical utility of lipoprotein(a) and the ApoB/ApoA-I ratio in the risk assessment of acute coronary syndrome: from single biomarkers to integrated risk stratification. [PDF]

Front Cardiovasc Med
Lu Z, Li P, Li R, Guo X, Li S, Wang J.
europepmc   +1 more source

Die tRNA‐Modifikation Geranyl‐2‐thiouridin ermöglicht eine RNA‐Lipid Assoziation

Angewandte Chemie, EarlyView.
Wir berichten über die Herstellung mono‐ bis tri‐geranylierter RNA und über die Assoziation hydrophober RNA mit Membranen für einen künftigen effizienten Einbau von RNA in Liposomen. ZUSAMMENFASSUNG Die Verpackung von RNA in Lipid‐Nanopartikeln zum Schutz und Transport war für die Entwicklung von mRNA‐Impfstoffen und Medikamenten entscheidend.
Johannes Singer, Kathrin Halter, Chun‐Yin Chan, Thomas Carell   +3 more
wiley   +1 more source

Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter. [PDF]

Nat Commun
Pang J, Chen Y, Qiao W, Ju Z, Zhu X, Chang S, Wang L, Zhang Z, Zerang Z, Xu S, Chen Y, Li C, Ying B, Ding BS, Chen H, Zhang S, Wei X, Tang X, Dong H.   +18 more
europepmc   +1 more source