Results 31 to 40 of about 219,582 (315)

Lipoprotein Abnormalities in Chronic Kidney Disease and Renal Transplantation

Life, 2021
Chronic kidney disease (CKD) is one of the most important risk factors for cardiovascular disease (CVD). Despite the kidney having no direct implications for lipoproteins metabolism, advanced CKD dyslipidemia is usually present in patients with CKD, and ...
Carlo Maria Barbagallo, Angelo Baldassare Cefalù, Antonina Giammanco, Davide Noto, Rosalia Caldarella, Marcello Ciaccio, Maurizio Rocco Averna, Emilio Nardi   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin

Journal of Lipid Research
Lipoprotein(a) [Lp(a)] is a cardiovascular risk factor, and there is considerable interest in developing Lp(a)-lowering therapeutics for cardiovascular prevention.
Craig A. Swearingen, John H. Sloan, Grace M. Rhodes, Robert W. Siegel, Nico Bivi, Yuewei Qian, Robert J. Konrad, Michael Boffa, Marlys Koschinsky, John Krege, Giacomo Ruotolo, Stephen J. Nicholls, Laura F. Michael, Yi Wen   +13 more
doaj   +1 more source

Model class A and class L peptides increase the production of apoA-I-containing lipoproteins in HepG2 cells

Journal of Lipid Research, 2004
Class A peptides inhibit atherosclerosis and protect cells from class L peptide-mediated lysis. Because the cytolytic process is concentration dependent, we hypothesized that at certain concentrations both classes of peptides exert similar effect(s) on ...
Nassrin Dashti, Geeta Datta, Medha Manchekar, Manjula Chaddha, G.M. Anantharamaiah   +4 more
doaj   +1 more source

Lipid and Lipoprotein Metabolism in Microglia

Frontiers in Physiology, 2020
Microglia, once viewed as static bystanders with limited homeostatic functions, are now considered key players in the development of neuroinflammatory and neurodegenerative diseases.
Bailey A. Loving, Kimberley D. Bruce
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

Molecular Metabolism, 2018
Objectives: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA ...
Abhishek K. Singh, Binod Aryal, Balkrishna Chaube, Noemi Rotllan, Luis Varela, Tamas L. Horvath, Yajaira Suárez, Carlos Fernández-Hernando   +7 more
doaj   +1 more source

The lipid substrate preference of CETP controls the biochemical properties of HDL in fat/cholesterol-fed hamsters

Journal of Lipid Research, 2021
: Cholesteryl ester transfer protein (CETP) modulates lipoprotein metabolism by transferring cholesteryl ester (CE) and triglyceride (TG) between lipoproteins. However, differences in the way CETP functions exist across species.
Richard E. Morton, Daniel Mihna, Yan Liu
doaj   +1 more source

Lipoprotein Metabolism, Protein Aggregation, and Alzheimer’s Disease: A Literature Review

International Journal of Molecular Sciences, 2023
Alzheimer’s disease (AD) is the most common form of dementia. The physiopathology of AD is well described by the presence of two neuropathological features: amyloid plaques and tau neurofibrillary tangles. In the last decade, neuroinflammation and cellular stress have gained importance as key factors in the development and pathology of AD.
Elena Grao-Cruces, Carmen M. Claro-Cala, Sergio Montserrat-de la Paz, Clevio Nobrega   +3 more
openaire   +5 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source