Results 51 to 60 of about 3,148 (231)

Comparison of Model‐Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue‐Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. McCrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +18 more
wiley   +1 more source

Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina [PDF]

Langmuir 31 (26) 7346 - 7354 (2015), 2015
We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity. We study the bulk properties of phospholipid/nanoparticle dispersions and determine the nature of their interactions.
arxiv   +1 more source

Rheocarna treatment for non‐dialysis patients

Therapeutic Apheresis and Dialysis, EarlyView.
Abstract Introduction Rheocarna has attracted attention as an alternative therapy for severe chronic limb‐threatening ischemia, and there have been reports of its usefulness. However, most of these reports have been on dialysis patients, and there are few reports on the treatment conditions and efficacy in non‐dialysis patients.
Atsushi Ohkubo, Takatoshi Sakurasawa, Yuki Hoshikawa, Masaya Deushi, Mana Usui, Shigeto Komori, Ayako Itagaki, Hiroko Yamamoto, Hiroshi Seshima, Naoki Kurashima, Soichiro Iimori, Shotaro Naito   +11 more
wiley   +1 more source

Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis

American Journal of Perinatology Reports, 2012
Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear ...
Akl C. Fahed, Anwar H. Nassar
doaj   +1 more source

Highlights From the 2nd Turin International Workshop on Liver Machine Perfusion

Artificial Organs, Volume 49, Issue 4, Page 716-721, April 2025.
ABSTRACT The 2nd Turin International Workshop on Liver Machine Perfusion took place in Turin, Italy, on November 22, 2024. Leading experts came together to discuss the current applications, limitations, and future directions of this technology, with a primary focus on but not limited to liver transplantation.
Damiano Patrono, Nicola De Stefano, Rebecca Panconesi, Paulo N. Martins, Renato Romagnoli, Meeting Collaborators   +5 more
wiley   +1 more source

Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia

Journal of Lipid Research, 1997
Apheresis only partially controls raised low density lipoprotein cholesterol levels in patients with homozygous familial hypercholesterolemia, who usually respond poorly to lipid-lowering drugs.
A D Marais, R P Naoumova, J C Firth, C Penny, C K Neuwirth, G R Thompson   +5 more
doaj  

The design of retroviral vectors used in the CAR‐T products, risk management, and future perspective

MedComm, Volume 6, Issue 2, February 2025.
This article compares gamma retroviral and lentiviral vectors, discussing packaging systems and SIN vector design. It also covers risks of secondary malignancies linked to retroviral vectors and strategies to minimize them. The article explores the regulatory framework, safety monitoring, and future safety improvements for CAR‐T therapy, emphasizing a ...
Huifang Yin, Xuejing Wei
wiley   +1 more source

Bifurcation analysis of a free boundary model of plaque formation associated with the cholesterol ratio [PDF]

arXiv, 2020
The low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio has been shown a high correlation with the cardiovascular risk assessment. Is it possible to quantify the correlation mathematically? In this paper, we develop a bifurcation analysis for a mathematical model of the plaque formation with a free boundary in the early stage
arxiv  

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

Journal of Cosmetic Dermatology, Volume 24, Issue 2, February 2025.
ABSTRACT Background There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet‐rich plasma represents an abundant source of exosomes. Aim To present evidence on the use of platelet‐rich plasma‐derived exosomes in dermatology and discuss current technical limitations.
Aditya K. Gupta, Tong Wang, Jeffrey A. Rapaport, Mesbah Talukder   +3 more
wiley   +1 more source

Beyond cholesterol—pleiotropic effects of lipoprotein apheresis

Therapeutic Apheresis and Dialysis, 2022
AbstractCardiovascular disease is a leading cause of mortality worldwide, which is caused mainly by atherosclerosis, a chronic inflammatory disease of blood vessels. Therefore, atherosclerosis represents a complex disorder, which induces damage or imbalance on different levels: for example, genes, cytokines, lipoproteins, cells, vessels, and organs ...
Volker J. J. Schettler, Elke Schettler
openaire   +3 more sources