Results 61 to 70 of about 3,148 (231)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundApheresis is an important treatment for reducing low‐density lipoprotein cholesterol (LDL‐C) in patients with familial hypercholesterolemia (FH). We systematically reviewed the current literature surrounding LDL‐C apheresis for FH.
Anthony Wang +7 more
doaj +1 more source
Oxysterols in Vascular Cells and Role in Atherosclerosis [PDF]
Implication of Oxysterols and Phytosterols in Aging and Human
Diseases, 1440, Springer International Publishing, pp.213-229, 2024, Advances
in Experimental Medicine and BiologyAtherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL display proatherogenic activities through multiple and complex mechanisms which lead to dysfunctions of vascular ...
arxiv +1 more source
Hypercholesterolemia and inflammation—Cooperative cardiovascular risk factors
European Journal of Clinical Investigation, Volume 55, Issue 1, January 2025.Abstract Background Maintaining low concentrations of plasma low‐density lipoprotein cholesterol (LDLc) over time decreases the number of LDL particles trapped within the artery wall, slows the progression of atherosclerosis and delays the age at which mature atherosclerotic plaques develop.
Antonio Gallo +7 more
wiley +1 more source
Cardiovascular Therapeutics, Volume 2025, Issue 1, 2025.Background: Recent studies have indicated that cluster of differentiation 36 (CD36) is closely linked to dyslipidemia and early‐onset coronary artery disease (EOCAD). This study is aimed at investigating the impacts of CD36 gene variants on lipid profiles and EOCAD risk.
Zhi Luo, Lingwei Lv, Victor Garcia
wiley +1 more source
Lipoprotein apheresis to treat elevated lipoprotein (a)1
Journal of Lipid Research, 2016 An elevated plasma concentration of lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. Life style modification and currently available drugs either fail to effectively lower plasma Lp(a) levels or do not result in clinical ...
Elisa Waldmann, Klaus G. Parhofer
doaj
A Dynamical Model of Lipoprotein Metabolism [PDF]
arXiv, 2006 We present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state.
arxiv
Case Reports in Endocrinology, Volume 2025, Issue 1, 2025.Background: Severe hypertriglyceridemia (triglycerides (TGs) >1000 mg/dL, >11.3 mmol/L) is a rare but potentially morbid condition in pregnancy. Physiological changes in pregnancy may unmask or exacerbate an underlying defect in TG metabolism. When conventional therapies are ineffective in controlling TG levels, a personalized management approach is ...
Nisha Suda +5 more
wiley +1 more source
Effect of hypertension on low-density lipoprotein transport within a multi-layered arterial wall: modelling consistent with experiments [PDF]
arXiv, 2016 The influence of hypertension on low-density lipoproteins intake into the arterial wall is an important factor for understanding mechanisms of atherosclerosis. It has been experimentally observed that the increased pressure leads to the higher level of the LDL inside the wall.
arxiv
Modelling the inflammatory process in atherosclerosis: a nonlinear renewal equation [PDF]
arXiv, 2017 We present here a population structured model to describe the dynamics of macrophage cells. The model involves the interactions between modified LDL, monocytes/macrophages, cytokines and foam cells. The key assumption is that the individual macrophage dynamics depends on the amount of lipoproteins it has internalized.
arxiv
Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins
British Journal of Pharmacology, Volume 181, Issue 23, Page 4733-4749, December 2024.Abstract In recent years, various approaches have been undertaken to eliminate lipoproteins co‐isolated with extracellular vesicles, as they were initially regarded as contaminating entities. However, novel discoveries are reshaping our perspective.
Krisztina Németh +12 more
wiley +1 more source