Results 51 to 60 of about 2,738 (166)

Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia

JACC: Case Reports
We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age.
Hayato Tada, MD, Hirofumi Okada, MD, Masa-aki Kawashiri, MD, Masayuki Takamura, MD   +3 more
doaj   +1 more source

Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series

Journal of Clinical Apheresis, Volume 41, Issue 2, April 2026.
ABSTRACT Immunoadsorption selectively eliminates circulating antibodies in antibody‐mediated diseases. Iron deficiency is the most common cause of anemia; however, the potential role of immunoadsorption in contributing to iron depletion remains insufficiently established.
Noemi E. Ginthör, Tobias Niedrist, Gerold Schwantzer, Alexander H. Kirsch, Werner Ribitsch, Andras Deak, Michael Kolland, Daniel Leitinger, Kathrin Eller, Alexander R. Rosenkranz, Katharina Artinger   +10 more
wiley   +1 more source

Serum Proteomic Analysis of Lipoprotein Apheresis in Patients with Hyperlipidemia

Zhipu Xuebao
Hyperlipidemia is a chronic disease characterized by elevated cholesterol and triglyceride levels in the blood, and has been identified as a common risk factor for many cardiovascular diseases, such as atherosclerosis, heart disease, stroke and obesity ...
Dong XU, Ye-xiao-qing YANG, Rong LIU, Zhong-han HU, Ding-feng LYU, Ke-qi TANG   +5 more
doaj   +1 more source

Transcatheter Intra‐Arterial Delivery of a Platelet‐Derived Extracellular Vesicle‐Enriched Preparation for Attenuating Skeletal Muscle Ischaemia‐Reperfusion Injury in a Rodent Forelimb Model

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Extracellular vesicles (EVs) are non‐replicating, lipid membrane‐bound nanoparticles released by most eukaryotic cells into the extracellular space. When derived from platelets, a subset of EVs can exhibit remarkable anti‐inflammatory and antioxidant properties, making them attractive candidates to attenuate sterile inflammatory states such as
Omar A. Selim, Aida Sarcon, Atta Behfar, Chunfeng Zhao, Steven L. Moran   +4 more
wiley   +1 more source

Aggressive lipid-lowering therapy before and after revascularization in patients with stable coronary artery disease

Медицинский совет, 2013
The review presents data on the effectiveness of lipid profile correction with maximum doses of statins, primarily atorvastatin, and lipoprotein apheresis.
R. N. Adzhiev, M. S. Safarova, M. V. Yezhov, Y. G. Matchin   +3 more
doaj   +1 more source

Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Background Studies comparing treatment strategies based on initiation timing—such as starting PCSK9 inhibitor (PCSK9i) therapy sooner versus later after a myocardial infarction (MI)—are prone to immortal time bias. Clone‐censor‐weight methods can address these issues and allow the researcher to emulate a trial in which patients are assigned to
Thomas Cars, Stefan Gustafsson, Queenie Chan, Nafeesa Dhalwani, Shia T. Kent, Andrew Briggs, Chris P. Gale, Anselm Gitt, J. Wouter Jukema, Philippe Gabriel Steg, Johan Sundström, Stefan James, Emil Hagström, M. Alan Brookhart   +13 more
wiley   +1 more source

Dextran-Sulfate Plasma Adsorption Lipoprotein Apheresis in Drug Resistant Primary Focal Segmental Glomerulosclerosis Patients: Results From a Prospective, Multicenter, Single-Arm Intervention Study

Frontiers in Pediatrics, 2019
Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or ...
Rupesh Raina, Rupesh Raina, Vinod Krishnappa, Vinod Krishnappa, Cheryl Sanchez-Kazi, Alejandro Quiroga, Katherine E. Twombley, Robert Mathias, Megan Lo, Ronith Chakraborty, Shefali Mahesh, Julia Steinke, Timothy Bunchman, Joshua Zaritsky   +13 more
doaj   +1 more source

Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients

International Journal of Vascular Medicine, 2016
Objective. To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment. Methods. We measured brachial artery flow-mediated dilation
Kevin D. Ballard, Eunice Mah, Yi Guo, Richard S. Bruno, Beth A. Taylor, Jo Ellen Beam, Donna M. Polk, Paul D. Thompson   +7 more
doaj   +1 more source

From platelets to particles: Optimizing extracellular vesicle isolation in a National Blood Centre

Vox Sanguinis, Volume 121, Issue 3, Page 245-253, March 2026.
Abstract Background and Objectives Platelet‐derived extracellular vesicles (PEVs) are submicron, membrane‐bound particles released upon platelet activation, with a recognized role in haemostasis, inflammation and immunoregulation. PEVs remain insufficiently characterized in blood products.
Y. Chintala, A. Waters, F. McGrath, A. Lorusso, C. Wynne, S. Meaney   +5 more
wiley   +1 more source

Platelet aggregation and lipoprotein levels in a patient with familial hypercholescholesterolemia after selective LDL-apheresis

São Paulo Medical Journal
Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after aphereis selective for low-density lipoprotein (LDL), a lipid-lowering procedure.This treatment reduced plasmatic levels of total and LDL-cholesterol, apo ...
Madalena Nunes da Silva Pares, Elbio Antonio D'Amico, José Mauro Kutner, Dalton de Alencar Fischer Chamone, Sergio Paulo Bydlowski   +4 more
doaj   +1 more source