Results 141 to 150 of about 96,115 (285)

Alipogene tiparvovec: a long journey of risk-benefit ratio assessment of gene therapy products

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2018
According to EMA, advanced therapy medicinal products include, inter alia, therapeutic systems containing nucleic acids used for replacement or repair of genetic defects.
R. N. Alyautdin   +6 more
doaj  

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarkers of cognitive decline, but their role in early ADAD is unclear.
Lina Pineda‐Lopez   +14 more
wiley   +1 more source

Association of Remnant Cholesterol With Self‑Reported Trouble Sleeping and Mediation by Depression

open access: yesBrain and Behavior, Volume 16, Issue 1, January 2026.
Remnant cholesterol was positively and linearly associated with self‐reported trouble sleeping in U.S. adults, and depression partially mediated this relationship. Monitoring remnant cholesterol may help identify individuals at higher risk of sleep problems and related cardiometabolic consequences.
Qichao Yang   +3 more
wiley   +1 more source

Effects of Platelet-Derived Growth Factor on the Synthesis of Lipoprotein Lipase in Human Monocyte–Derived Macrophages [PDF]

open access: bronze, 1995
Toshimori Inaba   +9 more
openalex   +1 more source

Mechanisms of Energy Balance in Obesity

open access: yes, 1984
The proper understanding of obesity requires a multifaceted approach. Behavioral considerations of eating and activity patterns do not account for the large between- and within-subjects variance associated with the energy-balance equation.
McMinn, Mark R.
core  

Sumac (Rhus coriaria L.) and Human Metabolic Health: A Systematic Review and Meta‐Analysis

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Sumac (Rhus coriaria L.) supplementation enhances glycemic control and lipid metabolism, indicating potential cardiometabolic benefits in reducing cardiovascular disease risk factors. ABSTRACT Background Rhus coriaria L. (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids ...
Ali Jafari   +9 more
wiley   +1 more source

Effects of Clinofibrate on Lipoprotein Lipase Activity

open access: diamond, 1986
Mitsunobu Kawamura   +5 more
openalex   +2 more sources

Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Integrated framework for tirzepatide in HFpEF management. Through metabolic, haemodynamic, structural and anti‐inflammatory pathways, tirzepatide modifies the disease trajectory of HFpEF, leading to improvements in symptoms, functional capacity and reduction in HF events.
Hamza A. Abdul‐Hafez   +9 more
wiley   +1 more source

Sulfated Polysaccharides in the Hallmarks of Metabolic Syndrome: Functions and Mechanisms

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The SPs sources are very diverse, including various fishes, sea cucumbers, seaweeds, etc. These SPs are able to improve the glucose and lipid metabolism disorders, hormonal dysregulation, oxidative stress, inflammatory response, complications, and gut homeostasis of MetS by regulating biochemical indicators related to MetS. ABSTRACT Metabolic syndrome (
Fuqiang Zhao   +9 more
wiley   +1 more source

Abnormal Lipoprotein Lipase in Familial Exogenous Hypertriglyceridemia [PDF]

open access: bronze, 1973
Paul H. Schreibman   +3 more
openalex   +1 more source

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