Results 131 to 140 of about 89,489 (249)

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Alipogene tiparvovec: a long journey of risk-benefit ratio assessment of gene therapy products

Регуляторные исследования и экспертиза лекарственных средств, 2018
According to EMA, advanced therapy medicinal products include, inter alia, therapeutic systems containing nucleic acids used for replacement or repair of genetic defects.
R. N. Alyautdin, B. K. Romanov, A. P. Pereverzev, A. O. Chikalo, N. D. Bunyatyan, V. A. Merkulov, A. N. Mironov   +6 more
doaj  

GPIHBP1 Autoantibody‐Related Hypertriglyceridemia in Children: A Report of Two Cases and a Review of Pediatric Cases From the Literature

Molecular Genetics &Genomic Medicine, Volume 14, Issue 5, May 2026.
We report two young children with severe hypertriglyceridemia lacking monogenic causes. Both were ANA‐positive, with confirmed anti‐GPIHBP1 antibodies. Immunosuppressive therapy (hydroxychloroquine ± prednisolone) effectively reduced triglycerides. GPIHBP1 autoantibody‐related hypertriglyceridemia is an important pediatric cause, requiring accurate ...
Rai‐Hseng Hsu, Wuh‐Liang Hwu, Feng‐Jung Yang, Ni‐Chung Lee, Yin‐Hsiu Chien   +4 more
wiley   +1 more source

Lipoprotein lipase deficiency.

Journal of postgraduate medicine, 2000
A rare case of a 3 month old child with lipoprotein lipase deficiency who presented with bronchopneumonia is reported. After noticing lipaemic serum and lipaemia retinalis, a diagnosis of hyperlipoproteinaemia was considered. Lipoprotein lipase deficiency was confirmed with post heparin lipoprotein lipase enzyme activity estimation.
K N, Shankar, H S, Bava, J, Shetty, M K, Joshi   +3 more
openaire   +1 more source

Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High‐Fat Meals

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
We applied a latent class mixed model to cluster individuals based on their postprandial triglyceride response curves after consumption of high‐fat meals. Three clusters with different triglyceride response patterns were identified. This approach holds the potential to be used for identifying metabolically dysfunctional individuals.
Jiaying Hu, Matteo D'Alessandro, Patrik Hansson, Kirsten B Holven, Magne Thoresen, Stine Marie Ulven   +5 more
wiley   +1 more source

Adipose Tissue‐Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice

Obesity, Volume 34, Issue 5, Page 1068-1080, May 2026.
ABSTRACT Objective This study aimed to assess iron oxide magnetic nanoparticles (MNPs) for adipose tissue‐targeted therapeutics to restore adipose tissue function and insulin sensitivity in obesity. Methods The insulin‐sensitizing effects of rosiglitazone and known adverse effects were leveraged for this proof‐of‐concept assessment of adipose tissue ...
Jakob E. Ostberg, Zeeshan Ahmed, Katayoun Saatchi, Parleen K. Pandher, Yamna Rahim, Urs O. Häfeli, Sarah L. Gray   +6 more
wiley   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Physical Activity, Sedentary Time, and Obesity in Adolescents: Differences by School Grade

Journal of School Health, Volume 96, Issue 5, May 2026.
ABSTRACT Background To better understand the key behavioral factors for adolescent obesity, this study investigated the independent and combined associations of physical activity (PA) and sedentary time (ST) with obesity prevalence across different school grades. Methods Cross‐sectional data from 614,943 adolescents in the Korea Youth Risk Behavior Web‐
Doyoung Gwak, Younghwan Choi, Yunmin Han, Yeon Soo Kim   +3 more
wiley   +1 more source

Lipoprotein Lipase [PDF]

, 2020
openaire   +1 more source