Results 111 to 120 of about 46,304 (223)

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

Effect of Arabica Coffee Husk on Plasma Lipids and Obesity on Albino Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Feeding on a high‐fat diet supplemented with Arabica coffee husks (CH) for 8 weeks led to an improvement in plasma lipids and adipose tissues in rats compared to the high‐fat diet. ABSTRACT Hyperlipidemia is a major risk factor for the development of cardiovascular diseases.
Shaheed Mohammed Alshaikhsaleh
wiley   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4521-4549, June 2026.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source

Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria

MedComm, Volume 7, Issue 6, June 2026.
In phenylketonuria (PKU), elevated phenylalanine (Phe) increases hepatic fibroblast growth factor 21 (FGF21) and thyroid hormones, enhancing brown adipose tissue (BAT) thermogenesis in patients. Central FGF21 reproduces this phenotype in rodents via reduced hypothalamic AMP‐activated protein kinase (AMPK) activity in the ventromedial nucleus of the ...
Noemí López‐Rey, Alba Cabaleiro, María P. Pata, Marion Peyrou, Ánxela Estévez‐Salguero, Paola Fernández‐Sanmartín, Donald A. Morgan, Vitor Ferreira, Paula Sánchez‐Pintos, Cintia Folgueira, Carlos Diéguez, Adela Urisarri, Ismael González‐García, Luisa M. Seoane, Kamal Rahmouni, Francesc Villarroya, María L. Couce, Rubén Nogueiras, Miguel López   +18 more
wiley   +1 more source

GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain. [PDF]

Proc Natl Acad Sci U S A
Liu M, Hung M, Kozlov E, Hung M, Colaço-Gaspar M, Roy S, Tu Y, Magaki SD, Williams CK, Andaloussi Mäe M, Johnson ECB, Siegel RW, Konrad RJ, Ploug M, Betsholtz C, Beigneux AP, He L, Fong LG, Young SG.   +18 more
europepmc   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Cardiac Metabolomic Alterations in Diabetes: Interplay with Lipoprotein Lipase-A Systematic Review. [PDF]

Int J Mol Sci
Gu J, Han X, Chen X, Lyu A, Cheung KCP.
europepmc   +1 more source

Impact of Moderate‐Intensity Multicomponent Training on Cardiometabolic Health‐Related Outcomes in Older Adults With Overweight and Obesity: A 9‐Month Quasi‐Experimental Single‐Arm Pretest‐Posttest Study

Australasian Journal on Ageing, Volume 45, Issue 2, June 2026.
ABSTRACT Objective The aim of this study was to investigate the effects of a moderate‐intensity multicomponent training (MCT) program on body composition, physical function, glycaemic control and lipid profiles in overweight and obese older people. Methods This single‐arm quasi‐experimental study included 48 male (n = 10) and female (n = 38) overweight
Enzo Berbery, Vitor de Salles Painelli, Paulo Vitor Suto Aizava, Marilene Ghiraldi de Souza Marques, Endriw Domingues Noronha, Déborah Cristina de Souza Marques, Kan Oishi, Jordan Hernandez‐Martinez, Pablo Valdés‐Badilla, Braulio Henrique Magnani Branco   +9 more
wiley   +1 more source