Results 101 to 110 of about 46,304 (223)
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
The Journal of Pathology, Volume 269, Issue 3, Page 363-380, July 2026.Abstract Dystrophinopathies are caused by pathogenic variants in the DMD gene, resulting in partial (Becker) or complete loss (Duchenne) of dystrophin. Becker (BMD) and Duchenne muscular dystrophy (DMD) are characterized by progressive muscle wasting, fatty replacement, fibrosis, and loss of function.
Laura GM Heezen +14 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.Dietary norbixin (0.15 g/kg) optimally promotes growth, immunocompetence, antioxidant defence, gut microbial balance, carotenoid accumulation, and overall nutritional quality in Macrobrachium nipponense. ABSTRACT Background Natural carotenoids have gained considerable attention in aquaculture due to their potential to enhance growth performance ...
Mohammad Ettefaghdoost +2 more
wiley +1 more source
Levothyroxine Treatment During Pregnancy: A Metabolomics Study
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT Levothyroxine is one of the most prescribed drugs during pregnancy. Our aim was to determine levothyroxine treatment‐associated changes in the metabolite profiles and link these to the health of the newborn. Metabolite profiles of 118 levothyroxine‐treated and 118 healthy control pregnancies were determined with nuclear magnetic resonance ...
Olli Kärkkäinen +3 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5810-5826, July 2026.ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6162-6171, July 2026.ABSTRACT Aims Tirzepatide, an injectable glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) receptor agonist (RA), is approved for weight management in several regions. Oral GLP‐1 RAs, such as semaglutide, are under investigation to improve convenience, acceptance and adherence versus injectable formulations ...
Andreea Ciudin +7 more
wiley +1 more source
Obesity Reviews, Volume 27, Issue 7, July 2026.ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso +7 more
wiley +1 more source
Alipogene tiparvovec: a long journey of risk-benefit ratio assessment of gene therapy products
Регуляторные исследования и экспертиза лекарственных средств, 2018 According to EMA, advanced therapy medicinal products include, inter alia, therapeutic systems containing nucleic acids used for replacement or repair of genetic defects.
R. N. Alyautdin +6 more
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Context‐Dependent Effects of Apolipoprotein A2 on Lipid Metabolism and Atherogenesis
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Proposed model of the pro‐atherogenic role of APOA2 in dyslipidemia. Under conditions of dyslipidemia (ldlr−/− and apoe−/− mice), APOA2 promotes a reduction in VLDL through its conversion to LDL via an LDLR‐independent pathway. LDL is then deposited to the aorta and aortic root. In the ldlr−/− mice, the presence of APOE may mitigate the rate of VLDL to
Evangelia Zvintzou +9 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Integrated transcriptomic, single‐cell, pseudotime, cell–cell communication, human tissue, and in vivo analyses define a dynamic four‐gene axis across the MASLD continuum. Progressive CYP2C19 downregulation and AKR1B10, COL1A2, and SPP1 upregulation link metabolic dysfunction to disease progression, while AKR1B10 knockdown or CYP2C19 overexpression ...
Kejun Liu +5 more
wiley +1 more source