Results 81 to 90 of about 93,526 (325)

Linkage of Low-Density Lipoprotein Size to the Lipoprotein Lipase Gene in Heterozygous Lipoprotein Lipase Deficiency [PDF]

The American Journal of Human Genetics, 1999
Small low-density lipoprotein (LDL) particles are a genetically influenced coronary disease risk factor. Lipoprotein lipase (LpL) is a rate-limiting enzyme in the formation of LDL particles. The current study examined genetic linkage of LDL particle size to the LpL gene in five families with structural mutations in the LpL gene.
Gail P. Jarvik, John E. Hokanson, Ellen M. Wijsman, John D. Brunzell, Melissa A. Austin   +4 more
openaire   +3 more sources

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

The Ser447–Ter mutation of the lipoprotein lipase gene relates to variability of serum lipid and lipoprotein levels in monozygotic twins1

Journal of Lipid Research, 1998
Studies on monozygotic twins support a role for genetic determinants of plasma lipid, lipoprotein, and apolipoprotein levels. Gene variants of the enzyme lipoprotein lipase have been shown to associate with dyslipidemia and coronary artery disease.
James A. Thorn, Edward W.A. Needham, Raj K. Mattu, Joseph Stocks, David J. Galton   +4 more
doaj   +1 more source

Use of LC‐MS to characterize host cell protein removal during depth filtration

Biotechnology Progress, EarlyView.
Abstract The removal of host cell proteins (HCPs) is crucial in biopharmaceutical production, as residual impurities can impact product safety and efficacy. While a number of studies have demonstrated that depth filtration can provide significant HCP removal, there is little information on its effectiveness in removing specific HCPs.
Liang‐Kai Chu, Ehsan Espah Borujeni, Xuankuo Xu, Andrew L. Zydney   +3 more
wiley   +1 more source

PLTP activity in premenopausal women: relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance

Journal of Lipid Research, 2000
Plasma phospholipid transfer protein (PLTP) is thought to play a major role in the facilitated transfer of phospholipids between lipoproteins and in the modulation of high density lipoprotein (HDL) particle size and composition.
Susan J. Murdoch, Molly C. Carr, John E. Hokanson, John D. Brunzell, John J. Albers   +4 more
doaj   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

ESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori, Sergio Davinelli, Armando Ferrera, Alessandro Medoro, Carlo Barsali, Allegra Battistoni, Maurizio Volterrani, Massimo Volpe, Luciano Saso, Speranza Rubattu   +9 more
wiley   +1 more source

Accelerated lipoprotein uptake by transplantable hepatomas that express hepatic lipase

Journal of Lipid Research, 1998
To test the hypothesis that hepatic lipase plays a key role in lipoprotein removal in vivo, a novel system was used. Hepatoma cells (HTC 7288c) were transfected with a cDNA encoding hepatic lipase in culture and grown as solid tumors in vivo. In culture,
Charles Donner, Sungshin Choi, Michael Komaromy, Allen D. Cooper   +3 more
doaj   +1 more source

Gut Microbiota‐Bile Acid Metabolism Axis Drive Anti‐Diabetic Effects of Polygonatum cyrtonema Polysaccharide on Glycolipid Metabolism and Intestinal Inflammation

Food Frontiers, EarlyView.
PCP‐80% could lessen the pathophysiology of T2DM in terms of controlling blood glucose/lipid levels and enhancing intestinal barrier function, via modulating the intricate web of intestinal microbiota/BAs/BAs signaling pathways. Red vertical arrows denote increases (HPCP‐80% vs. MC), blue vertical arrows indicate decreases (HPCP‐80% vs.
Xiaole Zhao, Bing Zheng, Tianxiang Ao, Jianhua Xie, Yi Chen, Hesham El‐Seedi, Hairong Huang, Baoting Liu, Qiang Yu   +8 more
wiley   +1 more source

A comparison of lipoprotein lipase activity and adipocyte differentiation in growing male rats

Journal of Lipid Research, 1977
During adipose tissue development changes in lipoprotein lipase activity per adipocyte precede significant changes in fat cell size. Lipoprotein lipase activity per adipocyte increases fourfold from the second to seventh postnatal week. Furthermore, when
E Hietanen, M R C Greenwood
doaj   +1 more source

Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]

, 2013
Peer reviewedPublisher ...
Martin, Samuel A.M., Pooley, Nicholas J., Secombes, Christopher J., Tacchi, Luca   +3 more
core   +2 more sources