Results 81 to 90 of about 91,018 (321)

Obesity: A Biobehavioral Point of View

, 1990
Excerpt: If you ask an overweight person, “Why are you fat?’, you will, almost invariably, get the answer, “Because 1 eat too much.” You will get this answer in spite of the fact that of thirteen studies, six find no significant differences in the ...
Acheson K. J., Acheson K. J., Benedict F. G., Bennett W., Bjorntorp P., Borjeson M., Bray G. A., Bray G. A., Brook C. D. G., Brook C. G. D., Cleary M. P., DeLuise M., Despres J. P., DiGirolamo M., Festing M. F. W., Flatt J. P., Flatt J. P., Galton D. J., Garrow J. S., Gasquet P., Gruen R., Gruen R. K., Hensel H., Hogan S., Itallie T. B., Itallie T. B., Kern P. A., Landsberg L., Lin M. H., McMinn M. R., Morgan B. L. G., Newsholme E. A., Rath E. A., Rodin J., Rothwell N. J., Schurz Y., Schwartz R. S., Schwartz R. S.   +37 more
core   +1 more source

Population Pharmacokinetics and Exposure‐Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 (ANGPTL3) inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C), independent of low‐density lipoprotein receptor, in patients with homozygous familial hypercholesterolemia (HoFH). A population pharmacokinetic (PK)/pharmacodynamic (PD) model was previously developed to characterize ...
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Yuhuan Wang, Poulabi Banerjee, Robert Pordy, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +8 more
wiley   +1 more source

Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine.

Journal of Lipid Research, 1992
The effect of castanospermine (CSTP), an inhibitor of glucosidase I, on processing, activity, and secretion of lipoprotein lipase was studied in 3T3-L1 adipocytes.
H Masuno, EJ Blanchette-Mackie, CJ Schultz, AE Spaeth, RO Scow, H Okuda   +5 more
doaj  

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Lipoprotein lipase deficiency with pancreatitis in mink: biochemical characterization and pathology

Journal of Lipid Research, 1997
A severe hyperlipemia in mink, with a pattern that suggested recessive inheritance, was observed at a farm in Norway. On a normal mink diet, affected animals had grossly elevated levels of plasma triglycerides which decreased towards normal on a low-fat ...
B Christophersen, K Nordstoga, Y Shen, T Olivecrona, G Olivecrona   +4 more
doaj  

Mechanisms of Energy Balance in Obesity

, 1984
The proper understanding of obesity requires a multifaceted approach. Behavioral considerations of eating and activity patterns do not account for the large between- and within-subjects variance associated with the energy-balance equation.
McMinn, Mark R.
core  

Chromosome‐level genome assembly and population genomic analysis provide insights into the genetic diversity and adaption of Schizopygopsis younghusbandi on the Tibetan Plateau

Integrative Zoology, EarlyView.
We have constructed the chromosome‐scale genome and investigated the evolutionary genomics of Schizopygopsis younghusbandi, a fish species native to the Yarlung Tsangpo River on the Tibetan Plateau. Our study indicated that this species diverged from other Schizothoracine fish approximately 4.2 million years ago, during the Neogene Tibetan uplift ...
Chaowei ZHOU, Yan ZHOU, Luohao XU, Fei LIU, Luo LEI, He GAO, Junting LI, Suxing FU, Yuting DUAN, Yougang TAN, Weihua MAO, Qiming WANG, Rongzhu ZHOU, Shijun XIAO, Chuan LIU, Haiping LIU   +15 more
wiley   +1 more source

Chylomicron protein content and the rate of lipoprotein lipase activity

Journal of Lipid Research, 1976
Chylomicrons isolated from rat intestinal lymph were incubated with plasma. Protein transfer to chylomicrons, reaction rate with purified lipoprotein lipase, and content of lipase cofactor were determined.
C J Fielding, P E Fielding
doaj  

Glucagon and Plasma Lipoprotein Lipase

Experimental Biology and Medicine, 1974
SummarySubcutaneous administration of 1.0 mg glucagon to 15 fasted normal people caused significant increase of plasma lipoprotein lipase-like activity in 1 hr. The activity is termed lipase-like since coconut oil emulsion rather than isolated chylomicrons was used as substrate.
Lucille Corbo, Raymond Caren
openaire   +3 more sources

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source