The characterisation of the ectodomain shedding of the low density lipoprotein receptor [PDF]
, 2009 Includes abstract. Includes bibliographical references (leaves 142-155)
Parker, Ayesha
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Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster[S]
Journal of Lipid Research, 2015 In terrestrial insects, cuticular hydrocarbons (CHCs) provide protection from desiccation. Specific CHCs can also act as pheromones, which are important for successful mating.
Claude Wicker-Thomas +8 more
doaj +1 more source
The role of dimerisation in the cellular trafficking of G-protein-coupled receptors [PDF]
, 2010 The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate ...
Milligan, Graeme
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Journal of Lipid Research, 2011 Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with nanomolar affinity.
Yan G. Ni +29 more
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More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. [PDF]
Neuron, 2014 Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse ...
Lane-Donovan C, Philips GT, Herz J.
europepmc +2 more sources
Drosophila Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake. [PDF]
PLoS Genetics, 2015 Lipophorin, the main Drosophila lipoprotein, circulates in the hemolymph transporting lipids between organs following routes that must adapt to changing physiological requirements.
Míriam Rodríguez-Vázquez +4 more
doaj +1 more source
Journal of Lipid Research, 1996 We have isolated two fractions of very low density lipoprotein particles in human plasma that lack apolipoprotein (apo) E by combined anti-apoE and heparin affinity chromatography of whole plasma followed by ultracentrifugation.
E Campos +3 more
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Lipoprotein receptors in Alzheimer's disease
, 2006 Lipoprotein receptors have important roles in pathological processes that lead to Alzheimer's disease (AD). Previously, they were believed to act mainly by modulating the neuronal metabolism of cholesterol and apolipoprotein E, major risk factors for ...
Willnow, T.E., Andersen, O.M.
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Identification of the nucleotide sequence of the lipoprotein lipase gene as well as its role in the development of hyperlipidemia and pancreatitis in the Miniature Schnauzer [PDF]
, 2005 Lipoprotein Lipase (LPL) is a key enzyme in lipid transport. It catalyses the hydrolysis of the triacylglycerol component of chylomicrons and very low-density lipoproteins (VLDL), providing non-esterified fatty acids for tissue utilization.
Schickel, Ralph
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