More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. [PDF]
Neuron, 2014 Lane-Donovan C, Philips GT, Herz J.
europepmc +2 more sources
An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]
, 2018 Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances +2 more
core +2 more sources
Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]
, 1999 Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C +27 more
core +1 more source
Journal of Lipid Research, 2015 Methionine sulfoxide reductase A (MsrA), a specific enzyme that converts methionine-S-sulfoxide to methionine, plays an important role in the regulation of protein function and the maintenance of redox homeostasis.
Yan-Yong Xu +6 more
doaj +1 more source
Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]
, 2017 No abstract ...
Packard, Chris J.
core +1 more source
Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor
Journal of Lipid Research, 2007 Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic +5 more
doaj +1 more source
Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. [PDF]
, 2018 The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear.
Aberg, Judith A +5 more
core +1 more source
The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
Journal of Lipid Research, 2017 The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role
Courtney Lane-Donovan, Joachim Herz
doaj +1 more source
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +3 more sources
Journal of Lipid Research, 2017 Familial hypercholesterolemia (FH) is a heritable condition of severely elevated LDL cholesterol, caused predominantly by autosomal codominant mutations in the LDL receptor gene (LDLR).
Michael A. Iacocca +6 more
doaj +1 more source