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AbstractLipoprotein(a) [Lp(a)] is an atherogenic lipoprotein with a strong genetic regulation. Up to 90% of the concentrations are explained by a single gene, theLPAgene. The concentrations show a several-hundred-fold interindividual variability ranging from less than 0.1 mg/dL to more than 300 mg/dL. Lp(a) plasma concentrations above 30 mg/dL and even
openaire +4 more sources
Beta (β)-amyloid (Aβ) is a causative protein of Alzheimer’s disease (AD). In the pathogenesis of AD, the apolipoprotein (apo) A-I and high-density lipoprotein (HDL) metabolism is essential for the clearance of Aβ.
Kyung-Hyun Cho
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The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19.
Kyung-Hyun Cho
doaj +1 more source
Low serum high-density lipoproteins-cholesterol (HDL-C) levels and high blood pressure are linked to each other and are recognized as independent risk factors of cardiovascular disease and dementia. HDL can cross the blood–brain barrier to remove amyloid
Kyung-Hyun Cho, Jae-Ryong Kim
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We have produced and characterized six murine monoclonal antibodies to human apolipoprotein A-I named A-I-9, A-I-12, A-I-15, A-I-16, A-I-19, and A-I-57. All monoclonal antibodies were specific for apolipoprotein A-I and bound between 55% and 100% of 125I-
S Marcovina +4 more
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Lipoproteins of Mycobacterium tuberculosis : an abundant and functionally diverse class of cell envelope components [PDF]
Mycobacterium tuberculosis remains the predominant bacterial scourge of mankind. Understanding of its biology and pathogenicity has been greatly advanced by the determination of whole genome sequences for this organism.
Harrington, Dean, Sutcliffe, Iain
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Hepatic lipase:structure/function relationship, synthesis,and regulation
Hepatic lipase (HL) is a lipolytic enzyme, synthesized by hepatocytes and found localized at the surface of liver sinusoid capillaries. In humans, the enzyme is mostly bound onto heparan-sulfate proteoglycans at the surface of hepatocytes and also of ...
Bertrand Perret +5 more
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Immunochemical studies on human plasma lipoproteins [PDF]
Some years ago, a series of human serum lipoproteins, distinguishable by their hydrated densities and lipid-protein ratios were recognized and isolated by ultracentrifugal techniques (1).
Aladjem, Frederick +2 more
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While low apolipoprotein A-I (apoA-I) levels are primarily associated with increased high density lipoprotein (HDL) fractional catabolic rate (FCR), the factors that regulate the clearance of HDL from the plasma are unclear.
Sylvie Braschi +3 more
doaj +1 more source
Spirochetal Lipoproteins and Immune Evasion. [PDF]
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani +2 more
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