Results 1 to 10 of about 116,976 (246)

Lipoprotein(a) [PDF]

MMW - Fortschritte der Medizin, 2021
AbstractLipoprotein(a) [Lp(a)] is an atherogenic lipoprotein with a strong genetic regulation. Up to 90% of the concentrations are explained by a single gene, theLPAgene. The concentrations show a several-hundred-fold interindividual variability ranging from less than 0.1 mg/dL to more than 300 mg/dL. Lp(a) plasma concentrations above 30 mg/dL and even
openaire   +4 more sources

Structural and Functional Impairments of Reconstituted High-Density Lipoprotein by Incorporation of Recombinant β-Amyloid42

Molecules, 2021
Beta (β)-amyloid (Aβ) is a causative protein of Alzheimer’s disease (AD). In the pathogenesis of AD, the apolipoprotein (apo) A-I and high-density lipoprotein (HDL) metabolism is essential for the clearance of Aβ.
Kyung-Hyun Cho
doaj   +1 more source

Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines, 2021
The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19.
Kyung-Hyun Cho
doaj   +1 more source

Rapid Decrease in HDL-C in the Puberty Period of Boys Associated with an Elevation of Blood Pressure and Dyslipidemia in Korean Teenagers: An Explanation of Why and When Men Have Lower HDL-C Levels Than Women

Medical Sciences, 2021
Low serum high-density lipoproteins-cholesterol (HDL-C) levels and high blood pressure are linked to each other and are recognized as independent risk factors of cardiovascular disease and dementia. HDL can cross the blood–brain barrier to remove amyloid
Kyung-Hyun Cho, Jae-Ryong Kim
doaj   +1 more source

Immunochemical characterization of six monoclonal antibodies to human apolipoprotein A-I: epitope mapping and expression.

Journal of Lipid Research, 1990
We have produced and characterized six murine monoclonal antibodies to human apolipoprotein A-I named A-I-9, A-I-12, A-I-15, A-I-16, A-I-19, and A-I-57. All monoclonal antibodies were specific for apolipoprotein A-I and bound between 55% and 100% of 125I-
S Marcovina, S Fantappie, A Zoppo, G Franceschini, AL Catapano   +4 more
doaj   +1 more source

Hepatic lipase:structure/function relationship, synthesis,and regulation

Journal of Lipid Research, 2002
Hepatic lipase (HL) is a lipolytic enzyme, synthesized by hepatocytes and found localized at the surface of liver sinusoid capillaries. In humans, the enzyme is mostly bound onto heparan-sulfate proteoglycans at the surface of hepatocytes and also of ...
Bertrand Perret, Laurence Mabile, Laurent Martinez, François Tercé, Ronald Barbaras, Xavier Collet   +5 more
doaj   +1 more source

Apolipoprotein A-I charge and conformation regulate the clearance of reconstituted high density lipoprotein in vivo

Journal of Lipid Research, 1999
While low apolipoprotein A-I (apoA-I) levels are primarily associated with increased high density lipoprotein (HDL) fractional catabolic rate (FCR), the factors that regulate the clearance of HDL from the plasma are unclear.
Sylvie Braschi, Tracey A-M. Neville, Marie-Claude Vohl, Daniel L. Sparks   +3 more
doaj   +1 more source

Argan Oil Exerts an Antiatherogenic Effect by Improving Lipids and Susceptibility of LDL to Oxidation in Type 2 Diabetes Patients

International Journal of Endocrinology, 2011
In this study, we investigate the effect of argan oil consumption on serum lipids, apolipoproteins (AI and B), CRP, and LDL susceptibility to oxidation in type 2 diabetic patients which are known to have a high level of cardiovascular risk due to lipid
M. M. Ould Mohamedou, K. Zouirech, M. El Messal, M. S. El Kebbaj, A. Chraibi, A. Adlouni   +5 more
doaj   +1 more source

Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity

Journal of Lipid Research, 2004
The effect of apolipoprotein A-II (apoA-II) on the structure and stability of HDL has been investigated in reconstituted HDL particles. Purified human apoA-II was incorporated into sonicated, spherical LpA-I particles containing apoA-I, phospholipids ...
Jonathan Boucher, Tanya A. Ramsamy, Sylvie Braschi, Daisy Sahoo, Tracey A-M. Neville, Daniel L. Sparks   +5 more
doaj   +1 more source

Interaction of low-density lipoproteins of serum with hemin*†

Journal of Lipid Research, 1962
The interaction of low-density lipoproteins of human serum with hemin and the nature of the oxidative denaturation of low-density lipoproteins of serum catalyzed by hemin was studied by means of spectrophotometric and ultracentrifugal analyses and by ...
Toshiro Nishida, Fred A. Kummerow
doaj   +1 more source