The Current Status of Research on High-Density Lipoproteins (HDL): A Paradigm Shift from HDL Quantity to HDL Quality and HDL Functionality. [PDF]
Int J Mol Sci, 2022 The quantity of high-density lipoproteins (HDL) is represented as the serum HDL-C concentration (mg/dL), while the HDL quality manifests as the diverse features of protein and lipid content, extent of oxidation, and extent of glycation. The HDL functionality represents several performance metrics of HDL, such as antioxidant, anti-inflammatory, and ...
Cho KH.
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The pleiotropic vasoprotective functions of high density lipoproteins (HDL). [PDF]
J Biomed Res, 2017 The pleiotropic functions of circulating high density lipoprotein (HDL) on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation, endothelial activation and apoptosis in peripheral vessels.
Boyce G, Button E, Soo S, Wellington C.
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Relationship of the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index with antioxidant enzymes and with the oxLDL/HDL index [PDF]
Gaceta Médica de México, 2023 The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index is a predictive factor for atherosclerosis, which is associated with oxidative modifications.To assess the association of the index with oxidative stress markers.444 subjects were included and were clinically, anthropometrically and biochemically characterized; superoxide dismutase,
Eduardo Monjaraz-Guzmán +8 more
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Effects of superoxide anion attack on the lipoprotein HDL
Molecular and Cellular Biochemistry, 2022 AbstractHigh-density lipoprotein (HDL) is an anti-atherosclerotic lipoprotein. Thanks to the activity of apolipoprotein ApoA1, the principal protein component of HDL, this last is responsible for converting cholesterol into ester form and transporting excessive cholesterol to the liver (“reverse cholesterol transport” RCT). When HDL undergoes oxidation,
Napolitano G. +5 more
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High-Density Lipoprotein (HDL) Triglyceride and Oxidized HDL: New Lipid Biomarkers of Lipoprotein-Related Atherosclerotic Cardiovascular Disease [PDF]
Antioxidants, 2020 Lipid markers are well-established predictors of vascular disease. The most frequently measured lipid markers are total cholesterol, high-density lipoprotein (HDL)-cholesterol (HDL-C), LDL cholesterol (LDL-C), and triglyceride. HDL reduces atherosclerosis by multiple mechanisms, leading to a reduced risk of cardiovascular disease, and HDL-C, as a ...
Tomoyuki Ito, Tomoyuki Ito, Fumiaki Ito
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 The strong inverse relationship between HDL level and risk for coronary artery disease has been attributed to different mechanisms. More than 30 years ago, Glomset1 proposed that HDL mediates the transfer of cholesterol from peripheral tissues to the liver, where the sterol and its oxygenated products are excreted into the bile.
Jay W. Heinecke +2 more
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Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results. [PDF]
, 2018 Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements.
Canaud, Bernard +11 more
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Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome [PDF]
, 1987 The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis.
Appel +22 more
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Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. [PDF]
, 1994 Lipoproteins isolated from normal human plasma can bind and neutralize bacterial lipopolysaccharide (LPS) and may represent an important mechanism in host defense against gram-negative septic shock. Recent studies have shown that experimentally elevating
Kane, JP +4 more
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HDL is the major lipoprotein carrier of plasma F2-isoprostanes [PDF]
Journal of Lipid Research, 2009 Enhanced oxidative stress is implicated in the development of atherosclerosis in humans and animal models. F(2)-isoprostanes are formed in vivo via free radical peroxidation of arachidonic acid, and their quantification has allowed assessment of oxidative stress in vivo.
Julie M. Proudfoot +5 more
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