Results 241 to 250 of about 494,667 (340)

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Dysregulated high-density lipoprotein and low-density lipoprotein subfractions increase metabolic dysfunction-associated steatotic liver disease risk: a study of patients across body mass index categories. [PDF]

Front Nutr
Yu HY, Zhang JQ, Sun PQ, Li QH, Lin H, Wang JY, Qian XJ, Yang XD, Hu C, Tian P, Jiang YY, Lin GQ.   +11 more
europepmc   +1 more source

The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice

Obesity, EarlyView.
ABSTRACT Objective We aimed to examine the effect of obesity on the plasma free fatty acid (FFA) carrier proteome in mice. Methods From 6 to 20 weeks of age, male and female C57BL/6J wild‐type mice were fed either a low‐fat diet (10% of kilocalories from fat) or a high‐fat diet (60% of kilocalories from fat), and leptin‐deficient ob/ob mice were fed a ...
Keigo Tomoo, Yi Zhang, Ariana Zoe Diaz Portalatin, Gregory C. Henderson   +3 more
wiley   +1 more source

ANGPTL3, Apo CIII, Leptin and Triglycerides Are Elevated in Metastatic Prostate Cancer. [PDF]

Cancers (Basel)
Boulay G, Khodr M, Bergeron AC, Wong Chong É, Joncas FH, Castonguay C, Robitaille K, Hovington H, Fradet V, Bergeron A, Pouliot F, Blais J, Seidah NG, Calon F, Gangloff A.   +14 more
europepmc   +1 more source

Development and Validation of a Nomogram Incorporating Preoperative N‐Terminal Pro‐Brain Natriuretic Peptide to Predict Major Adverse Cardiovascular Events in Renal Transplant Recipients

Organ Medicine, EarlyView.
We developed and validated a preoperative nomogram incorporating NT‐proBNP to predict major adverse cardiovascular events in renal transplant recipients. Using a LASSO‐Cox model based on 582 training and 181 validation cases, we identified NT‐proBNP, age, body mass index, diabetes, and retransplantation as key predictors.
Guobin Wu, Chang Wang, Qihao Li, Shuangjin Yu, Linjie Peng, Jianliang Min, Weijie Lai, Haiwei Chen, Jiang Qiu, Guodong Chen   +9 more
wiley   +1 more source

Higher coronary heart disease mortality in South Asian compared with European men in the UK - prospective study [PDF]

, 2004
Chaturvedi, N, Forouhi, NG, McKeigue, P, Sattar, N   +3 more
core   +2 more sources

Residual risk in atherosclerotic cardiovascular disease after statin therapy: Clinical mechanisms and management strategies. [PDF]

World J Cardiol
Tan SH, Wu JL, Zhuo SX, Zhang Y, Wang M.
europepmc   +1 more source

Prevalence of non‐alcoholic fatty liver disease and its association with different combinations of weight status and metabolic abnormalities in children aged 6–18 years

Pediatric Investigation, EarlyView.
Children with non‐overweight combined with metabolic risk factors might increase the risk of non‐alcoholic fatty liver disease (NAFLD). These findings suggest that overweight and obesity should not be the sole criterion for NAFLD screening in children. In particular, more attention should be given to non‐overweight combined with metabolic abnormalities
Peiyu Ye, Luting Peng, Liwang Gao, Xiaonan Li, Qin Liu, Pei Xiao, Liang Wang, Xiaoyan Shi, Jun Ma, Yanhui Dong, Dongling Dai, Qinghua Yang, Xinchun Chen, Xin Fan, Naijun Wan, Jin Zhang, Bin Li, Lin Zhou, Guangsheng Wu, Lin Yang, Yan He, Yinkun Yan, Jie Mi   +22 more
wiley   +1 more source

Fenofibrate plus statin and ASCVD risk by triglyceride-rich lipoprotein cholesterol in 70,000 patients. [PDF]

J Lipid Res
Jang Y, Kim BJ, Jeong YW, Kang DR, Koh KK, Nordestgaard BG, Han SH.   +6 more
europepmc   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source