Results 141 to 150 of about 315,624 (316)

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

High density lipoprotein-induced cardiac prostacyclin synthesis in vitro: relationship to cardiac arachidonate mobilization.

Journal of Lipid Research, 1988
The objectives of this study were to characterize the effects of plasma lipoproteins on prostacyclin (PGI2) production by the Langendorff-perfused rabbit heart, and to determine the mechanism of lipoprotein-induced cardiac PGI2 production.
W A Van Sickle, H G Wilcox, K U Malik, A Nasjletti   +3 more
doaj   +1 more source

Birth outcome in relation to licorice consumption during pregnancy.

, 2001
A role for glucocorticoids is suspected in the etiology of low birth weight. The authors tested whether maternal consumption of glycyrrhizin (an inhibitor of cortisol metabolism) in licorice affects birth weight in humans. A sample of 1,049 Finnish women
Järvenpää, AL, McKeigue, PM, Strandberg, TE, Vanhanen, H   +3 more
core   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Human luteinized granulosa cells secrete apoB100-containing lipoproteins

Journal of Lipid Research, 2010
Thus far, liver, intestine, heart, and placenta have been shown to secrete apolipoprotein (apo)B-containing lipoproteins. In the present study, we first investigated lipoproteins in human follicular fluid (FF), surrounding developing oocytes within the ...
Thomas Gautier, Steffi Becker, Véronique Drouineaud, Franck Ménétrier, Paul Sagot, Jerzy-Roch Nofer, Sören von Otte, Laurent Lagrost, David Masson, Uwe J.F. Tietge   +9 more
doaj   +1 more source

Nonalcoholic Fatty Liver Disease Status and Its Associated Factors Among Patients With Type 2 Diabetes Mellitus in Adama Hospital Medical College, South Eastern Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Nonalcoholic fatty liver disease (NAFLD) is a condition of fat accumulation in hepatocytes, not because of excess alcohol intake and disease‐causing etiology. The disease occurrence is increased among patients with type 2 diabetes mellitus (T2DM) because of a strong pathophysiological link.
Mahider Shimelis Feyisa, Sintayehu Ambachew, Alemie Fentie Mebratie, Bruktawit Eshetu Ali, Rishan Hadgu Asefa, Elias Chane Asefa, Mahder Girma Asmamaw, Getnet Fetene   +7 more
wiley   +1 more source

ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan

Journal of Lipid Research, 2002
Retention of apolipoprotein (apo)B and apoE-containing lipoproteins by extracellular vascular proteoglycans is critical in atherogenesis. Moreover, high circulating apoC-III levels are associated with increased atherosclerosis risk.
Katherine Olin-Lewis, Ronald M. Krauss, Michael La Belle, Patricia J. Blanche, P.Hugh R. Barrett, Thomas N. Wight, Alan Chait   +6 more
doaj   +1 more source

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations. [PDF]

, 2020
"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population.
Williams, Paul T
core   +1 more source

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Longevity and muscle strength are heritable traits, and age‐related muscle weakness is a major contributor to disability in older adults. However, the susceptibility genes and shared genetic mechanisms underlying lifespan and sarcopenia remain unclear.
Yilong Lin, Yun Zhang, Shengjie Lin, Songsong Wang, Zhiqiang Que, Yue Zhang, Jing She, Ruidan Zhao, Jiawei Chen, Anqi Qiu, Shinan Wu, Ruiqin Yang, Liyi Zhang, Qingmo Yang   +13 more
wiley   +1 more source

Key Determinants of Weight Loss Trajectory Across Different Periods of a Behavioral Weight Loss Intervention

Obesity, Volume 34, Issue 2, Page 357-371, February 2026.
ABSTRACT Objective This longitudinal study aims to identify the key factors influencing the weight loss trajectory during a 24‐week intervention and their relevance at different stages of the treatment. Methods We studied 1252 participants (age 18–65 years) of a cognitive behavioral program to lose weight.
Rocío De la Peña‐Armada, Giovana Longo‐Silva, María Rodríguez‐Martín, Hui‐Wen Yang, Marta Garaulet   +4 more
wiley   +1 more source