Results 161 to 170 of about 45,302 (266)

APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1268-1286, May 2026.
Aim APOE genotype may affect statin therapy response. We conducted a meta‐analysis to update and quantify this association across various outcomes. Methods We searched seven databases (MEDLINE, Scopus, Web of Science, the Cochrane Library, APA PsycINFO, CINAHL Plus and ClinicalTrials.gov) on 9 May 2024.
Innocent G. Asiimwe   +4 more
wiley   +1 more source

Macrophage and Very Low Density Lipoprotein (VLDL) Metabolism

open access: yesThe Journal of Japan Atherosclerosis Society, 1984
Yoko FUMIYAMA   +5 more
openaire   +2 more sources

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics

open access: yesDiabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou   +13 more
wiley   +1 more source

Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency.

open access: yesThe Journal of biological chemistry, 2002
Although very low density lipoprotein (VLDL) receptor (VLDLr) knockout mice have been reported to have no lipoprotein abnormalities, they develop less adipose tissue than control mice when fed a high calorie diet. Mice that are deficient in adipose tissue expression of lipoprotein lipase (LpL) also have less fat, but only when crossed with ob/ob mice ...
Hiroaki, Yagyu   +7 more
openaire   +1 more source

Fucoxanthin Ameliorates MASLD by Directly Targeting GRP78 to Restore ER Homeostasis and Activate AMPK Signaling

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Proposed model of fucoxanthin in ameliorating MASLD via the GRP78‐AMPK axis. In MASLD, excessive lipid accumulation (FFA, TG, DNL) leads to ER stress activation (upregulation of CHOP, ATF6, IRE1) and GRP78 dysfunction, promoting hepatic lipid droplet (LD) formation. Fucoxanthin directly binds to GRP78, which in turn activates AMPK signaling.
Lin Zhang   +9 more
wiley   +1 more source

Exploring the Functional Potential of Date (Phoenix dactylifera) Seed Bioactives in Modulating Gut Microbiota in Diabetic Rats

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Date fruits (Phoenix dactilyfera L.) are widely produced with huge wasted by‐products (seeds/pits and fibers) in remarkable nutritional and economic potential value. This study aims to examine the impact of the functional properties of date seeds on health status and gut microbiota (GM) modulation in diabetic rats. Valorization of date seed by‐products
Nouf Abdullah Alharbi   +9 more
wiley   +1 more source

Investigating Novel Inflammatory Indices and Their Links to Mortality, Cancer, and Cardiovascular Disease: A 10‐Year Cohort Study

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
Abstract Background and Aims Inflammatory indices, including neutrophil‐to‐lymphocyte‐platelet ratio (NLPR), systemic immune‐inflammation index (SII), platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR) have been proposed as prognostic markers for mortality.
Mahboobeh Ghasemzadeh Rahbardar   +9 more
wiley   +1 more source

Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High‐Fat Meals

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
We applied a latent class mixed model to cluster individuals based on their postprandial triglyceride response curves after consumption of high‐fat meals. Three clusters with different triglyceride response patterns were identified. This approach holds the potential to be used for identifying metabolically dysfunctional individuals.
Jiaying Hu   +5 more
wiley   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

open access: yesAlimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg   +8 more
wiley   +1 more source

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