Results 161 to 170 of about 315,624 (316)

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarkers of cognitive decline, but their role in early ADAD is unclear.
Lina Pineda‐Lopez, David Aguillon, Juan Villar‐Vesga, Pablo Valderrama‐Carmona, Alejandro Guerrero, Anil Upreti, Said Arevalo‐Alquichire, Laura Correa, Karin Mendez‐Castellanos, Diana Castaño, Gloria P. Cardona‐Gomez, Geysson J. Fernandez, Leo A. Kim, Joseph F. Arboleda‐Velasquez, Rafael Posada‐Duque   +14 more
wiley   +1 more source

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.

Journal of Clinical Investigation, 2005
Kerry L Donnelly, Coleman I. Smith, S. Schwarzenberg, J. Jessurun, M. Boldt, E. Parks   +5 more
semanticscholar   +1 more source

Integrating mass spectrometry‐based multi‐omic signatures of extracellular vesicles: from discovery to clinical translation

Clinical &Translational Immunology, Volume 15, Issue 1, 2026.
Extracellular vesicles carry proteins, lipids and metabolites, reflecting cellular health and disease. This review examines how mass spectrometry‐based multi‐omics—proteomics, lipidomics and metabolomics is transforming EV characterisation. We address integration strategies, standardisation challenges and emerging technologies, bridging multi‐omics ...
Akila Wijerathna‐Yapa, Dimitri Aubert, Arutha Kulasinghe   +2 more
wiley   +1 more source

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

International Journal of Eating Disorders, Volume 59, Issue 1, Page 54-69, January 2026.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki   +15 more
wiley   +1 more source

Association of the Endothelial Nitric Oxide Synthase (eNOS) G894T Gene Polymorphism With Type 2 Diabetes Mellitus in a Tunisian Population

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
The eNOS G894T polymorphism is a significant genetic risk factor for type 2 diabetes in the studied Tunisian population. The T allele appears to confer susceptibility, likely through mechanisms involving impaired eNOS function, reduced NO production and subsequent endothelial dysfunction.
Afif Ba, Manel Ayoub, Sana Aboulkacem, Mariem Belhedi, Zied Aouni, C. Mazigh   +5 more
wiley   +1 more source

Triglyceride-rich very low-density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents. [PDF]

Diabetes Obes Metab, 2018
Tricò D, Natali A, Mari A, Ferrannini E, Santoro N, Caprio S.   +5 more
europepmc   +1 more source

CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins.

Arteriosclerosis, Thrombosis and Vascular Biology, 1997
D. Calvo, D. Gómez-Coronado, M. A. Lasunción, M. Vega   +3 more
semanticscholar   +1 more source

Lipid‐Lowering Potential of Food Formulations Based on Culinary‐Treated Flours of Dioscorea bulbifera (Dana) in Obese and Hyperlipidemic Rats

Food Safety and Health, Volume 4, Issue 1, Page 233-246, January 2026.
This graphical abstract highlights the nutritional management of obesity through food formulations based on the two varieties (white and black) of Dioscorea bulbifera yams that has undergone culinary treatments (boiling and braising). The results show that white Dioscorea bulbifera showed the best properties compared to black after the culinary ...
Fossouo Towa Patrik Florent, Maffo Tazoho Ghislain, Tekou Florian Amel, Kenfack Justine Odelonne, Zokou Ronice, Dangang Bossi Donald Séverin, Womeni Hilaire Macaire   +6 more
wiley   +1 more source

Fuc‐S, a New Degraded Polysaccharide From Fucoidan, Alleviates Type 2 Diabetes‐Associated Liver Injury Through Modulating Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Fuc‐S alleviated type 2 diabetes‐associated liver injury through gut microbiota‐SCFA‐liver axis regulation. Fuc‐S treatment significantly improved glucose tolerance, lipid metabolism, and liver function, while reducing hepatic steatosis and serum ALT/AST levels. Fuc‐S reinforced intestinal barrier integrity by upregulating tight junction proteins (ZO‐1
Bin Du, Caihong Cheng, Jinxiu Feng, Yue Liang, Wang Tao, Baojun Xu, Jiao Peng, Guangtao Zhang, Yuedong Yang   +8 more
wiley   +1 more source

LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction.

Journal of Clinical Investigation, 2001
Anita C.E. Vreugdenhil, A. Snoek, Cornelis van 't Veer, J. Greve, Wim A. Buurman   +4 more
semanticscholar   +1 more source