Results 21 to 30 of about 284,504 (254)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

The Differential Effects of HDL Subpopulations on Lipoprotein Lipase (LPL)-Mediated VLDL Catabolism [PDF]

Biomedicines, 2021
High-density lipoprotein (HDL) subpopulations functional assessment is more relevant for HDL anti-atherogenic activity than cholesterol level. The aim of the study was to assess the impact of HDL-2 and HDL-3 on lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL) catabolism related to hypertriglyceridemia development.
Ewa Wieczorek, Agnieszka Ćwiklińska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwińska, Maciej Jankowski   +5 more
openaire   +3 more sources

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease

Diabetes, 2020
Diabetes is now a pandemic disease. Moreover, a large number of people with prediabetes are at risk for developing frank diabetes worldwide. Both type 1 and type 2 diabetes increase the risk of atherosclerotic cardiovascular disease (CVD).
A. Chait, H. Ginsberg, T. Vaisar, J. Heinecke, I. Goldberg, K. Bornfeldt   +5 more
semanticscholar   +1 more source

Characterization of a very-low-density lipoprotein (VLDL)-associated cytotoxic factor [PDF]

British Journal of Cancer, 1981
A VLDL-associated cytotoxic factor was isolated from sera of pregnant rats and characterized. The inhibitory effect of this factor on the macromolecular synthesis of rat prostate adenocarcinoma cells (PA-III) was also examined. VLDL (Sf 20-400) was subfractionated by differential ultracentrifugal flotation and the Sf 100-400 fraction was associated ...
M. Pollard, S. Y. Chan
openaire   +3 more sources

Short-term effects of exercise on plasma very low density lipoproteins (VLDL) and fatty acids.

Medicine & Science in Sports & Exercise, 1999
PURPOSE In the fasted state the lipid fuels for muscle metabolism are free fatty acids (FFA) released either from intramuscular triglycerides (TG), plasma albumin, or TG in circulating very low density lipoproteins (VLDL). The purposes of this study were
E. Børsheim, S. Knardahl, A. Høstmark
semanticscholar   +1 more source

Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)

International Journal of Molecular Sciences, 2022
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours. Here, we present a brief review of the physiological role of VLDL and a systemic review of the emerging evidence supporting its pathological roles.
Jih-Kai Huang, Hsiang-Chun Lee
openaire   +2 more sources

Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids.

PLoS Biology, 2022
Triglycerides are carried in the bloodstream as part of very low-density lipoproteins (VLDLs) and chylomicrons, which represent the triglyceride-rich lipoproteins.
Lei Deng, Frank Vrieling, Rinke Stienstra, Guido J Hooiveld, Anouk L Feitsma, Sander Kersten   +5 more
doaj   +1 more source

Interaction of very low density lipoproteins (VLDL) with rabbit C-reactive protein.

Journal of Immunology, 1982
Rabbit CRP is similar to human CRP in structure, kinetics of appearance, and binding reactivities to phosphate esters and cationic polymers. CRP in rabbit acute-phase serum migrates either with gamma or with beta, pre-beta electrophoretic mobility, and ...
V. Cabana, H. Gewurz, J. Siegel
semanticscholar   +1 more source

Disrupted VLDL Features and Lipoprotein Metabolism in Sepsis [PDF]

, 2012
Gram-negative sepsis is an increasingly clinical syndrome triggered by exposure to bacterial lipopolysaccharide (LPS) or endotoxin. It is associated with a plethora of physiological and biochemical changes, known as acute-phase response (APR), including disturbances in serum lipid and lipoprotein levels (Khovidhunkit et al., 2004).
Patricia Aspichueta, Nerea Bartolomé, Xabier Buqué, Yolanda Chico, Begoña Ochoa, María José Martínez   +5 more
openaire   +3 more sources