Results 81 to 90 of about 23,433 (212)
The FEBS Journal, Volume 293, Issue 6, Page 1754-1770, March 2026.The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini +6 more
wiley +1 more source
Liposomal-polyene preliposomal powder and method for its preparation [PDF]
, 1993 A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one
Lenk, Robert P. +2 more
core +1 more source
High-dose amphotericin: yay or nay? A case series and literature review
Drugs in ContextInvasive fungal infections pose significant morbidity and mortality risks, particularly those caused by moulds. Available antifungal classes are limited by toxicities and are increasingly susceptible to resistance, particularly amongst challenging fungal
Kayla R Stover +3 more
doaj +1 more source
Clinical Medicine Insights: Case Reports, 2014 Amphotericin-B, a broad spectrum antifungal agent, has been known to cause adverse effects such as nephrotoxicity and infusion-related side effects such as fever, chills, rigor, and arthralgias. However, ototoxicity as an adverse effect of Amphotericin-B
PC Das +3 more
doaj +1 more source
PLoS Neglected Tropical DiseasesVisceral leishmaniasis (VL) is a severe and potentially fatal infection, with over 90% of reported cases occurring in East African countries including Chad, Djibouti, Eritrea, Ethiopia, Kenya, Somalia, South Sudan, Sudan, and Uganda, affecting mainly ...
Kishor M Wasan
doaj +1 more source
Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. [PDF]
, 2020 There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Alkhazraji, Sondus +8 more
core +1 more source
Antifungal activity of caspofungin in experimental infective endocarditis caused by Candida albicans
Memorias do Instituto Oswaldo CruzBACKGROUND Infective endocarditis is a disease characterised by heart valve lesions, which exhibit extracellular matrix proteins that act as a physical barrier to prevent the passage of antimicrobial agents.
Gerardo Becerra Victorio +7 more
doaj +1 more source
The use of K39 test in the diagnosis of visceral leishmaniasis [PDF]
, 2007 From time to time patients admitted with fever of unknown origin prove to be a diagnostic dilemma. While textbooks describe typical symptoms and signs, and also diagnostic tests, these are not always helpful.
Sciberras, Robert
core
Cryptococcal infection of the ventriculoperitoneal shunt in an immunocompetent patient [PDF]
, 2016 Patient: Male, 52 Final Diagnosis: Cryptococcal ventriculoperitoneal shunt infection Symptoms: Confusion • fever • Lethargy Medication: Amphotericin B • Flucytosine Clinical Procedure: Ventriculoperitoneal shunt removal Specialty: Infectious disease ...
Foong, Kap Sum +2 more
core +2 more sources
Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B
Case Reports in Infectious Diseases, 2015 Central nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients.
Demet Toprak +5 more
doaj +1 more source