Results 111 to 120 of about 1,901 (164)

Liposomal bupivacaine and novel local anesthetic formulations

Best Practice & Research Clinical Anaesthesiology, 2019
Novel preparations allowing for the extended duration of action of local anesthetics have many clinically relevant benefits. With regard to this, the development of liposomal bupivacaine has the potential to significantly impact patient care by improving perioperative pain control. The unique liposomal bilayer that encapsulates bupivacaine allows for a
Amit, Prabhakar, Ceressa T, Ward, Matthew, Watson, Jay, Sanford, Babar, Fiza, Vanessa, Moll, Rachel J, Kaye, O, Morgan Hall, Elyse M, Cornett, Richard D, Urman, Alan David, Kaye   +10 more
openaire   +4 more sources

Bupivacaine Versus Liposomal Bupivacaine For Pain Control

Drug Research, 2017
AbstractLocal infiltrations and regional blocks have been some of the effective ways employed to manage and control post-operative pain. One of the limitations of administration of local anesthesia drugs in post-operative conditions is its inability to act for a longer period of time.
Siavash, Beiranvand, Mahmoud Reza, Moradkhani   +1 more
openaire   +2 more sources

Characterization of exparel bupivacaine multivesicular liposomes

International Journal of Pharmaceutics, 2023
Exparel is a bupivacaine multivesicular liposomes (MVLs) formulation developed based on the DepoFoam technology. The complex composition and the unique structure of MVLs pose challenges to the development and assessment of generic versions. In the present work, we developed a panel of analytical methods to characterize Exparel with respect to particle ...
Minzhi Yu, Wenmin Yuan, Ziyun Xia, Yayuan Liu, Yan Wang, Xiaoming Xu, Jiwen Zheng, Anna Schwendeman   +7 more
openaire   +2 more sources

Liposomal Bupivacaine in Forefoot Surgery

Foot & Ankle International, 2015
Background: Liposomal bupivacaine is increasingly being utilized in attempts to provide prolonged local analgesia in the immediate postoperative period. The purpose of this study was to quantify the reduction in opioid consumption as well as postoperative pain scores in the postoperative period when liposomal bupivacaine is used at the conclusion of ...
Justin, Robbins, Cynthia L, Green, Selene G, Parekh   +2 more
openaire   +2 more sources

Bupivacaine Binding to Pegylated Liposomes

Anesthesia & Analgesia, 2009
Local anesthetic drugs, such as bupivacaine, can cause severe toxicity. Lipid emulsions have been proposed and used clinically for treating such cases. Liposomes may be an alternative for overdose treatment because of their unique structures and surface charges, which allows them to act as high affinity drug "sinks" and remove bupivacaine from solution.
Brett A, Howell, Anuj, Chauhan
openaire   +2 more sources

Liposomal Bupivacaine Versus Immediate-Release Bupivacaine for Postoperative Pain Control

Annals of Pharmacotherapy, 2021
Background Liposomal bupivacaine (LB) is increasingly being used for postoperative pain control, but there are conflicting efficacy data when compared with immediate-release bupivacaine (IRB). Objective To evaluate the comparative efficacies of LB and IRB for postoperative pain control in order to assess the formulary status of LB at our institution ...
Atul Dilawri, Marcia Wyman, Sneha Shah
openaire   +2 more sources

Liposomal bupivacaine for regional anesthesia

Current Opinion in Anaesthesiology, 2015
Using a regional block in a multimodal approach to postoperative analgesia management involves addressing, which local anesthetic and how much should be used to ensure adequate pain relief to reduce related morbidity and mortality. This article will review literature surrounding the recently approved formulation of slow release liposomal bupivacaine ...
Anna, Uskova, Jessica E, O'Connor
openaire   +2 more sources

Liposomal Bupivacaine versus Dexamethasone: Reply

Anesthesiology, 2023
David H, Kim, Jiabin, Liu, Christopher L, Wu, Stavros G, Memtsoudis   +3 more
openaire   +4 more sources

Liposomal Bupivacaine versus Dexamethasone: Comment

Anesthesiology, 2023
Habib Md Reazaul Karim, Pradipta Bhakta, Brian O’Brien   +2 more
openaire   +4 more sources

Single-shot interscalene block with liposomal bupivacaine vs. non-liposomal bupivacaine in shoulder arthroplasty

Journal of Shoulder and Elbow Surgery
Regional anesthesia is a valuable component of multimodal pain control in total shoulder arthroplasty (TSA), and multiple interscalene block anesthetic options exist, including nonliposomal interscalene bupivacaine (NLIB) and liposomal interscalene bupivacaine (LIB). The purpose of this study was to compare pain control and opioid consumption within 48
Samuel Lorentz, Jay M. Levin, Eric Warren, Eoghan T. Hurley, Frederic B. Mills, Bryan S. Crook, Emily Poehlein, Cynthia L. Green, W. Michael Bullock, Jeff C. Gadsden, Christopher S. Klifto, Oke Anakwenze   +11 more
openaire   +2 more sources