Results 1 to 10 of about 103,677 (295)

A Case Report of Subcutaneously Injected Liposomal Cannabidiol Formulation Used as a Compassion Therapy for Pain Management in a Dog

Frontiers in Veterinary Science, 2022
A 14-year-old intact mixed breed dog (26 kg) was submitted for a novel cannabidiol (CBD) analgesic treatment. The dog was cachectic and had a testicular neoplasia, hip and elbow osteoarthritis and severe cervical pain. Analgesic treatment included canine
Yael Shilo-Benjamini, Yael Shilo-Benjamini, Ahuva Cern, Daniel Zilbersheid, Atara Hod, Eran Lavy, Dinorah Barasch, Yechezkel Barenholz   +7 more
doaj   +1 more source

TLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study

Arthritis Research & Therapy, 2022
Background Corticosteroid injection for knee osteoarthritis is limited by its modest duration of treatment effect. The liposome formulation of dexamethasone sodium phosphate (TLC599) was developed for the sustained relief of osteoarthritis pain.
David J. Hunter, Chi-Ching Chang, James Cheng-Chung Wei, Hsiao-Yi Lin, Carl Brown, Tien-Tzu Tai, Chih-Feng Wu, Wing Chia-Ming Chuang, Sheue-Fang Shih   +8 more
doaj   +1 more source

Therapeutic Potential of Injectable Nano-Mupirocin Liposomes for Infections Involving Multidrug-Resistant Bacteria

Pharmaceutics, 2021
Antibiotic resistance is a global health threat. There are a few antibiotics under development, and even fewer with new modes of action and no cross-resistance to established antibiotics.
Ahuva Cern, Yaelle Bavli, Atara Hod, Daniel Zilbersheid, Shazad Mushtaq, Ayelet Michael-Gayego, Dinorah Barasch, Yael Feinstein Rotkopf, Allon E. Moses, David M. Livermore, Yechezkel Barenholz   +10 more
doaj   +1 more source

A Strategy to Treat COVID‐19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study

Clinical and Translational Science, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a newly identified pathogen causing the coronavirus disease 2019 (COVID‐19) pandemic. Hydroxychloroquine (HCQ), an antimalarial and anti‐inflammatory drug, has been shown to inhibit SARS‐CoV‐
Tien‐Tzu Tai, Tzung‐Ju Wu, Huey‐Dong Wu, Yi‐Chen Tsai, Hui‐Ting Wang, An‐Min Wang, Sheue‐Fang Shih, Yee‐Chun Chen   +7 more
doaj   +1 more source

Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis

Frontiers in Veterinary Science, 2023
IntroductionOsteoarthritis is a common disease in dogs resulting in chronic pain and decreased wellbeing. Common analgesics such as non-steroidal anti-inflammatories may fail to control pain and can produce major adverse effects. Study objectives were to
Yael Shilo-Benjamini, Yael Shilo-Benjamini, Eran Lavy, Nadav Yair, Joshua Milgram, Daniel Zilbersheid, Atara Hod, Dinorah Barasch, Wiessam Abu Ahmad, Ahuva Cern, Yechezkel Barenholz   +10 more
doaj   +1 more source

Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices

Micromachines, 2021
The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices.
Yoel Goldstein, Sarah Spitz, Keren Turjeman, Florian Selinger, Yechezkel Barenholz, Peter Ertl, Ofra Benny, Danny Bavli   +7 more
doaj   +1 more source

Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil [PDF]

Pharmaceutical Sciences Asia, 2022
Clitoria ternatea (butterfly pea) flower and Eugenia caryophyllus (clove) oil have been traditionally used as hair growth stimulating herbal and exhibited hair growth effects in vitro. This work prepared liposome loading with butterfly pea flower extract
Natchaporn Choochuen, Ampa Jimtaisong
doaj   +1 more source

Liposomal Bupivacaine (Bupigel) Demonstrates Minimal Local Nerve Toxicity in a Rabbit Functional Model

Pharmaceutics, 2021
We previously reported the development of a novel formulation of an ultra-long-acting local anesthetic based on bupivacaine encapsulated in large multivesicular liposomes (Bupisomes) embedded in hydrogel.
Yaelle Bavli, Malcolm Rabie, Yakov Fellig, Yoram Nevo, Yechezkel Barenholz   +4 more
doaj   +1 more source

Research-based findings on scope of liposome-based cosmeceuticals: an updated review

Future Journal of Pharmaceutical Sciences, 2022
Background Cosmeceuticals are cosmetic products with biologically active components that have drug-like benefits. Cosmeceuticals are currently rapidly growing segments encompassing the personal care industry and numerous topical cosmetics-based therapies
Tapan Kumar Shaw, Paramita Paul, Bappaditya Chatterjee   +2 more
doaj   +1 more source

Predicting liposome formulations by the integrated machine learning and molecular modeling approaches

Asian Journal of Pharmaceutical Sciences, 2023
Liposome is one of the most widely used carriers for drug delivery because of the great biocompatibility and biodegradability. Due to the complex formulation components and preparation process, formulation screening mostly relies on trial-and-error ...
Run Han, Zhuyifan Ye, Yunsen Zhang, Yaxin Cheng, Ying Zheng, Defang Ouyang   +5 more
doaj   +1 more source