Results 41 to 50 of about 183,250 (346)

Effect of surface charge of gold nanoparticles on fluorescence amplification of polydiacetylene-based liposomes

Journal of Experimental Nanoscience, 2020
Polydiacetylene (PDA)-based liposome have been attractive as sensory platforms owing to their applicability in simultaneous detection of colorimetric and fluorogenic signals.
Kyu Ha Park, Sangjin Oh, Jeonghyo Kim, Seung Yun Yang, Beum-Soo An, Dae Youn Hwang, Jae Ho Lee, Hong Sung Kim, Jaebeom Lee, Sungbaek Seo   +9 more
doaj   +1 more source

Quantitative modeling of the high-throughput production and in vivo kinetics of (drug-encapsulating) liposomes. [PDF]

PLoS ONE, 2010
In developing liposomes for in vivo use, it is important to design the liposomes to have optimal in vivo kinetics, and it is also necessary to identify optimal high-throughput production conditions for these liposomes.
Albert Wong
doaj   +1 more source

Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs

Pharmaceutics, 2023
Proteolysis-Targeting Chimeras (PROTACs) are a promising new technology in drug development. They have rapidly evolved in recent years, with several of them in clinical trials.
Ponien Kou, Elizabeth S. Levy, An D. Nguyen, Donglu Zhang, Shu Chen, Yusi Cui, Xing Zhang, Fabio Broccatelli, Jennifer Pizzano, Jennifer Cantley, Elizabeth Bortolon, Emma Rousseau, Michael Berlin, Peter Dragovich, Vijay Sethuraman   +14 more
doaj   +1 more source

Liposome production by microfluidics: potential and limiting factors

Scientific Reports, 2016
This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes.
D. Carugo, E. Bottaro, J. Owen, E. Stride, C. Nastruzzi   +4 more
semanticscholar   +1 more source

Predicting liposome formulations by the integrated machine learning and molecular modeling approaches

Asian Journal of Pharmaceutical Sciences, 2023
Liposome is one of the most widely used carriers for drug delivery because of the great biocompatibility and biodegradability. Due to the complex formulation components and preparation process, formulation screening mostly relies on trial-and-error ...
Run Han, Zhuyifan Ye, Yunsen Zhang, Yaxin Cheng, Ying Zheng, Defang Ouyang   +5 more
doaj  

Development of a rapid in vitro pre-screen for distinguishing effective liposome-adjuvant delivery systems

Scientific Reports, 2022
Liposomes are a strong supporting tool in vaccine technology, as they are a versatile system that not only act as antigen delivery systems but also adjuvants that can be highly effective at stimulating both innate and adaptive immune responses.
Laura A. J. Feather, Vinod Nadella, Elisabeth Kastner, Yvonne Perrie, Anthony C. Hilton, Andrew Devitt   +5 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

Beilstein Journal of Organic Chemistry, 2014
Cyclodextrins (CDs) can form polypseudorotaxanes (PPRXs) with drugs or drug carriers possessing linear polymers such as polyethylene glycol (PEG). On the other hand, PEGylated liposomes have been utilized as a representative anticancer drug carrier ...
Kayoko Hayashida, Taishi Higashi, Daichi Kono, Keiichi Motoyama, Koki Wada, Hidetoshi Arima   +5 more
doaj   +1 more source

Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

Asian Journal of Pharmaceutical Sciences, 2016
Various biotin-modified liposomes incorporated with docetaxel (DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome (PDL), 0.5% (mol) biotin
Chun Chu, Ping Xu, Haoyue Zhao, Qing Chen, Dawei Chen, Haiyang Hu, Xiuli Zhao, Mingxi Qiao   +7 more
doaj   +1 more source