Results 151 to 160 of about 338,765 (389)

A new method for preparation of phospholipid vesicles (liposomes) ‐ french press [PDF]

, 1979
Y. Barenholzt, Simon Amselem, Dov Lichtenberg   +2 more
openalex   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Coagulation Matters: ATIII‐Enriched Biomolecular Corona Enhances the Hemocompatibility of PEG Nanoparticles

Advanced Healthcare Materials, EarlyView.
Engineering of a functional protein corona with a synergistic heparin‐ATIII complex significantly improves hemocompatibility of PEG nanoparticles. Through deliberate engineering of the protein corona, a 4‐fold reduction in coagulation activation (F1 + 2) without inducing adverse thromboinflammatory reactions (CD11b, C5a) is achieved without disrupting ...
Vaidehi Londhe, Manfred F. Maitz, Triantafyllos Chavakis, Carsten Werner, Alessia C. G. Weiss, Quinn A. Besford   +5 more
wiley   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol

Journal of Lipid Research, 1980
When rat liver cytosol, possessing sterol carrier protein (SCP) activity was incubated with [3H]-squalene-phospholipid liposomes, cofactors, and rat liver microsomes, squalene from the liposomes was converted into sterols.
R J Morin, M V Srikantaiah
doaj  

Silibinin-Loaded Liposomes: The Influence of Modifications on Physicochemical Characteristics, Stability, and Bioactivity Associated with Dermal Application

Pharmaceutics
Background/Objectives: The aims of the presented study were the development of four types of silibinin-loaded liposomes (multilamellar liposomes—MLVs, sonicated small unilamellar liposomes—SUVs, UV-irradiated liposomes, and lyophilized liposomes) and ...
Amjed Abdullah Karkad, Andrea Pirković, Milena Milošević, Bojan Stojadinović, Katarina Šavikin, Aleksandar Marinković, Aleksandra A. Jovanović   +6 more
doaj   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation

International Journal of Nanomedicine, 2013
Yikang Dai,1 Rui Zhou,2 Lin Liu,1 Yi Lu,2 Jianping Qi,2 Wei Wu21Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 2Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy ...
Dai Y, Zhou R, Liu L, Lu Y, Qi J, Wu W
doaj  

Interaction of immunoglobulins with liposomes. [PDF]

, 1974
Gerald Weissmann, Ann Brand, E. C. Franklin   +2 more
openalex   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source