Results 171 to 180 of about 28,679 (286)

Equol Alleviates Postmenopausal Metabolic Dysfunction‐Associated Steatotic Liver Disease via the GPR30/PI3K Pathway

eFood, Volume 7, Issue 3, June 2026.
This study demonstrates that equol exerts a protective effect on metabolic dysfunction‐associated steatotic liver disease in both in vivo and in vitro by activating the GPR30/PI3K/Nrf2 signaling pathway. Equol's interaction with GPR30 and its ability to activate the PI3K/Nrf2 pathway provide a promising therapeutic strategy for treating metabolic ...
Hanqiang Cui, Bin Wang, Bo Zou, Guiming Zhang, Zhe Xu, Shuo Li, Jing Xu, Xiangmin Ni, Jian Wang   +8 more
wiley   +1 more source

Tacrolimus Inhibits Hepatic Ferroptosis Through Modulating SIRT7-Dependent NRF2 Activation in Diabetes. [PDF]

Antioxidants (Basel)
Wang S, Liu W, Cui F, Guo X, Li J.
europepmc   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

A defined multi-metabolite formulation derived from Salvia miltiorrhiza alleviates obesity-associated cardiac lipotoxicity via modulating mitochondrial dynamics. [PDF]

Front Pharmacol
Xu H, Kong J, Wu R, Chu Z, Zhang W, Zhao X, Zhang Z, An S.   +7 more
europepmc   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Effects and Mechanisms of Stevioside on Metabolic Dysfunction‐Associated Steatotic Liver Disease

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
SV has the potential to prevent or treat MASLD by improving hepatic lipid metabolism, enhancing anti‐inflammatory and antioxidant capacity, and attenuating hepatic fibrosis. ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects more than 30% of adults globally and has emerged as a significant public health concern ...
Kangjun Li, Changfa Zhang, Lili Kang, Yunping Mu, Zemin Li, Jingyi Zhang, Guowei Li   +6 more
wiley   +1 more source

Inflammatory and lipotoxicity mechanisms in obesity related CKD. [PDF]

Front Nephrol
Rico-Fontalvo J, Raad-Sarabia M, Montejo Hernández J, Rodríguez Yánez T, Caparroso Ramos LR, Parra Sánchez P, Ovalle Gomez AA, Quintero JJ, Daza-Arnedo R.   +8 more
europepmc   +1 more source

Hypertriglyceridemia‑Induced Acute Pancreatitis Compared With Non‐Hypertriglyceridemia Acute Pancreatitis: A Retrospective Case‐Control Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Hypertriglyceridemia‐induced acute pancreatitis (HTGAP) is a distinct clinical subtype of acute pancreatitis (AP), but comparative data remain limited. This study aimed to compare risk factors, disease severity, and clinical outcomes between patients with HTGAP and non‐HTGAP.
Zahra Farhangiyan, Leila Moradi, Mehrdad Vaziri, Elena Lak, Ferdos Zaman, Shooka Mohammadi   +5 more
wiley   +1 more source

Building safe lipid stores: Arabidopsis lipins shape lipid droplet biogenesis and lipid homeostasis. [PDF]

Plant Physiol
Shakir S.
europepmc   +1 more source

Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction

, 2013
Within the β-cell, there is evidence that sirtuin 1 (SIRT1), a key regulator of nutrient metabolism, plays a beneficial role on insulin secretion. Excess circulating fat, as seen in obesity, has been shown to be detrimental to β-cell function (“β-cell ...
Desai, Tejas
core