Results 211 to 220 of about 11,031 (247)
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including migration, proliferation and maturation, which are essential to achieve an organized formation of the vessel sprout.
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Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including migration, proliferation and maturation, which are essential to achieve an organized formation of the vessel sprout.
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic
Christopher L, Karp +4 more
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Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic
Christopher L, Karp +4 more
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Lipoxins and Aspirin-Triggered Lipoxins in Airway Responses
2003Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Bruce D, Levy +8 more
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Lipid Mediators: Lipoxin and Aspirin-Triggered 15-Epi-Lipoxins
Inflammation & Allergy-Drug Targets, 2006Lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) are emerging as major promoters of resolution of the inflammatory reaction. These eicosanoids, that carry a tetraene chromophore, derive from sequential lipoxygenase (LO) metabolism of arachidonic acid. Three principal routes of LX/ATL biosynthesis have been uncovered.
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Lipoxins: revelations on resolution
Trends in Pharmacological Sciences, 2001Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered
B, McMahon +3 more
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Tetrahedron Letters, 1986
The synthesis of four isomers of 5.14,15-triHETE is reported. The key step is the coupling of acetylene 11 (or 19) with epoxide 7 to afford alcohol 12 (or 20). Natural lipoxin B is found to correspond to a mixture of 14R-8-cis-1, 14R-8-trans-3 and 14S-8-trans-4.
J, Morris, D G, Wishka
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The synthesis of four isomers of 5.14,15-triHETE is reported. The key step is the coupling of acetylene 11 (or 19) with epoxide 7 to afford alcohol 12 (or 20). Natural lipoxin B is found to correspond to a mixture of 14R-8-cis-1, 14R-8-trans-3 and 14S-8-trans-4.
J, Morris, D G, Wishka
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Conformational analysis of lipoxin A, lipoxin B and their trans-isomers
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988Lipoxin A and lipoxin B (LXA and LXB) are formed from the oxygenation of arachidonic acid by interactions between the 5- and 15-lipoxygenases of human leukocytes. Each compound displays highly stereospecific biological actions. Here, we present a computational description of the following compounds: lipoxin A, (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-
Brasseur, Robert +4 more
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Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005Lipoxin A4 (LXA4) and aspirin-triggered 15-epi-LXA4 (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury. LXA4 and ATL and their metabolically stable analogues display potent inhibitory actions in human isolated cells and blood, including attenuation of expression of adhesion molecules on leukocytes and endothelial ...
János G, Filep +2 more
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Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins and their receptor ALX
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005Endogenous chemical mediators or autacoids play key roles in controlling inflammation and its programmed resolution. Among them, it is known that lipoxins (LX) and aspirin-triggered LX (ATL) evoke bioactions in a range of physiologic and pathophysiologic processes and serve as endogenous lipid/chemical mediators that stop neutrophilic infiltration and ...
Nan, Chiang +2 more
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Total synthesis of lipoxin A4 and lipoxin B4 from butadiene
Tetrahedron Letters, 2000The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids.
Rodriguez, A +4 more
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