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Lipoxins: endogenous regulators of inflammation
American Journal of Physiology-Renal Physiology, 2004Over the past decade, compelling in vivo and in vitro studies have highlighted lipoxins (LXs) and aspirin-triggered LXs (ATLs) as endogenously produced anti-inflammatory eicosanoids. LXs and ATLs elicit distinct anti-inflammatory and proresolution bioactions that include inhibition of leukocyte-mediated injury, stimulation of macrophage clearance of ...
Blaithin, McMahon, Catherine, Godson
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Lipoxin and Aspirin-Triggered 15-epi-Lipoxin Cellular Interactions Anti-Inflammatory Lipid Mediators
cclm, 1999AbstractEicosanoids are known to play important roles in inflammation. Recent findings have given rise to several new concepts regulating the generation of eicosanoids, illustrated in Figure 1. Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within vascular lumen by platelet-leukocyte interactions and at mucosal surfaces ...
C N, Serhan +4 more
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Lipoxin A 4 attenuates adipose inflammation
The FASEB Journal, 2012Aging and adiposity are associated with chronic low‐grade inflammation, which underlies the development of obesity‐associated complications, including type 2 diabetes mellitus (T2DM). The mechanisms underlying adipose inflammation may include macrophage infiltration and activation, which, in turn, affect insulin sensitivity of ...
E. Borgeson +7 more
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1995
Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
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Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
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The Lipoxins: Synthesis and Biosynthesis
1988Since the first report of their isolation in 19841,2 the lipoxins have generated considerable interest amongst researchers studying the lipoxygenase pathway. The interest has been due both to the novel structure and intreging pharmacological properties3,4,5 reported for these bio-molecules.
B, Fitzsimmons, J, Rokach
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Lipoxin formation in fish leucocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991Adherent leucocytes, consisting of mainly macrophages, isolated from the haemopoietic head kidney of five species of fish were challenged with calcium ionophore and the resulting lipoxygenase products were separated and identified by reverse-phase high performance liquid chromatography.
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Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we investigate the potential of the proresolving eicosanoid lipoxinA₄ (LXA₄) and its synthetic analog benzo-LXA₄ to prophylactically modulate fibrotic and inflammatory responses in a model of early renal fibrosis, unilateral ureteric obstruction (UUO).
Emma, Börgeson +9 more
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