Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas +2 more
wiley +1 more source
Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents. [PDF]
Tambe MS +4 more
europepmc +1 more source
Trained Immunity and Cardiovascular Risk: An Immunological Perspective
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden +3 more
wiley +1 more source
Embelin Mitigates the Impact of Perinatal Inflammation on Neuron Development by Inhibiting 5-Lipoxygenase-Mediated Ferroptosis. [PDF]
Zhang F +6 more
europepmc +1 more source
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli +12 more
wiley +1 more source
Alterations of Bioactive Lipid Profiles in the Retina Following Traumatic Optic Neuropathy in Mice. [PDF]
Kim MY +6 more
europepmc +1 more source
Histological and Cytological Responses of Genotypes From Capsicum spp. to Meloidogyne enterolobii
ABSTRACT Sweet and chilli peppers (Capsicum spp.) are widely cultivated horticultural crops, but they are highly susceptible to root‐knot nematodes (Meloidogyne spp.). Among them, Meloidogyne enterolobii stands out for its aggressive parasitism and the severe damage it causes to economically important crops. This study aimed to describe and compare the
Mônica Lau da Silva Marques +4 more
wiley +1 more source
Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis. [PDF]
Sefer AP +16 more
europepmc +1 more source

