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Anthocyanins as lipoxygenase inhibitors
Molecular Nutrition & Food Research, 2009AbstractHealth benefits associated with diets rich in anthocyanins are ascribed to multilevel biological activities including antioxidative and anti‐inflammatory effects. The present study addresses lipoxygenase inhibition as a mechanism by which anthocyanins may exert health promoting effects. The inhibitory potential of delphinidin (Dp), cyanidin (Cy)
Bastian, Knaup +3 more
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The structure and function of lipoxygenase
Current Opinion in Structural Biology, 1994Lipoxygenases are non-heme iron enzymes that catalyze the dioxygenation of polyunsaturated fatty acids, yielding hydroperoxides. The first crystal structures have recently been published, revealing an unusual iron site. There have also been substantial developments in the analysis of the kinetics of the reaction, including the observation of uniquely ...
M J, Nelson, S P, Seitz
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5-Lipoxygenase and atherosclerosis
Current Opinion in Lipidology, 20035-Lipoxygenase (5LO) was recently identified as a gene that makes an important contribution to atherosclerosis in mice and humans, but the underlying mechanism(s) remains unknown.Studies of the 5LO pathway in other disease areas suggest that 5LO could contribute to atherosclerosis at different levels, such as lesion initiation, growth and cellular ...
Margarete, Mehrabian, Hooman, Allayee
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Lipoxygenase isozymes of peanut
Lipids, 1975AbstractLipoxygenase was isolated and partially purified from peanut seed by ammonium sulfate precipitation, gel filtration, and ion exchange column chromatography. Three isozymes of lipoxygenase were identified. Two had pH optima of 6.2, and the other an optimum of 8.3. Molecular weight of each isozyme was 7.3×104, as determined by gel filtration. The
T H, Sanders +2 more
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
The initial steps in the biosynthesis of leukotrienes from arachidonic acid are carried out by the enzyme 5-lipoxygenase (5-LO). In intact cells, the helper protein 5-LO activating protein (FLAP) is necessary for efficient enzyme utilization of endogenous substrate.
M, Peters-Golden, T G, Brock
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The initial steps in the biosynthesis of leukotrienes from arachidonic acid are carried out by the enzyme 5-lipoxygenase (5-LO). In intact cells, the helper protein 5-LO activating protein (FLAP) is necessary for efficient enzyme utilization of endogenous substrate.
M, Peters-Golden, T G, Brock
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Plant and fungal lipoxygenases
Prostaglandins & Other Lipid Mediators, 2002Lipoxygenases (LOX) are ubiquitous in plants, and some are important for resistance to pathogens. The soybean LOX (SLOX) remain the prototypes for studying lipoxygenation. The 3-D structures of SLOX-1 and -3 reveal an N-terminal beta-barrel and a C-terminal catalytic domain.
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