Results 281 to 290 of about 46,425 (297)

Synthesis of new sulfonamides as lipoxygenase inhibitors

Bioorganic & Medicinal Chemistry, 2012
The present study describes a convenient method for the synthesis of new lipoxygenase inhibitors, 4-(toluene-4-sulfonylamino)-benzoic acids from p-amino benzoic acid. Reaction of p-amino benzoic acid with p-toluenesulfonyl chloride provided thirteen N- and O-alkylation products 4a-4m in moderate to good yields.
Ghulam, Mustafa, Islam Ullah, Khan, Muhammad, Ashraf, Iftikhar, Afzal, Sohail Anjum, Shahzad, Muhammad, Shafiq   +5 more
openaire   +2 more sources

Substituted coumarins as potent 5-lipoxygenase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2006
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Erich L, Grimm, Christine, Brideau, Nathalie, Chauret, Chi-Chung, Chan, Daniel, Delorme, Yves, Ducharme, Diane, Ethier, Jean-Pierre, Falgueyret, Richard W, Friesen, Jocelyne, Guay, Pierre, Hamel, Denis, Riendeau, Chantal, Soucy-Breau, Philip, Tagari, Yves, Girard   +14 more
openaire   +2 more sources

Catechol based inhibitors of 15-lipoxygenase

Bioorganic & Medicinal Chemistry Letters, 1996
Abstract A potent 15-lipoxygenase (15-LO) inhibitor, compound 6 , was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15- lipoxygenase.
Bradley D. Tait, Richard D. Dyer, Bruce J. Auerbach, Dirk Bornemeier, Linda Guilds-Zamarka, Maritza Oxender, Bruce D. Roth, Bharat K. Trivedi, Joseph A. Cornicelli   +8 more
openaire   +1 more source

Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors

Bioorganic & Medicinal Chemistry Letters, 1992
Abstract Vinylogous hydroxamic acids were prepared as inhibitors of 5-lipoxygenase. The synthesis and preliminary SAR of these relatively unexplored compounds are described. These compounds are potent 5-lipoxygenase inhibitors which do not inhibit other enzymes of the arachidonic acid cascade.
Stephen W. Wright, Donald J. Pinto, Susan R. Sherk, Alicia M. Green, Ronald L. Magolda   +4 more
openaire   +1 more source

Endogenous inhibitors of lipoxygenase

European Journal of Pharmacology, 1980
S A, Saeed, M, Drew, H O, Collier
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Lipoxygenase Inhibitors and Leukotriene Receptor Antagonists

1988
The object of this chapter is to give the reader an overview of the numerous agents that directly modulate the effects of the leukotriene section of the arachidonic acid cascade (Figure 8.1). These agents fall into two general categories: enzyme inhibitors and receptor antagonists.
B. J. Fitzsimmons, J. Rokach
openaire   +1 more source

Lipoxygenase inhibitors as potential cancer chemopreventives.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999
Mounting evidence suggests that lipoxygenase (LO)-catalyzed products have a profound influence on the development and progression of human cancers. Compared with normal tissues, significantly elevated levels of LO metabolites have been found in lung, prostate, breast, colon, and skin cancer cells, as well as in cells from patients with both acute and ...
V E, Steele, C A, Holmes, E T, Hawk, L, Kopelovich, R A, Lubet, J A, Crowell, C C, Sigman, G J, Kelloff   +7 more
openaire   +1 more source

5-Lipoxygenase-Inhibitors from Medicinal Plants

Planta Medica, 1986
H, Wagner, B, Fessler, B, Geyer, A, Daily   +3 more
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Cyclooxygenase and lipoxygenase inhibitors in cancer therapy

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1996
G, Ara, B A, Teicher
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[5-lipoxygenase inhibitors in asthma therapy].

Nihon rinsho. Japanese journal of clinical medicine, 1997
Leukotrienes are biological active lipids produced from arachidonic acid in cell membrane by the enzyme 5-lipoxygenase. During anaphylaxis, large amounts of leukotrienes are generated in the lungs, causing bronchoconstriction. Leukotrienes exacerbate asthma in different ways including cellular infiltration, chemotaxis aggregation, and degranulation ...
openaire   +1 more source