Results 151 to 160 of about 4,073 (218)

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair. [PDF]

Sci Adv
Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y.   +12 more
europepmc   +1 more source

Abstract 1289 NAD+ kinase 2 fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism

Dohun Kim, R. Kesavan, Trishna Dey, Cameron J. Menezes, Austin Marckx, Prakash Priyadarshi Praharaj, Stewart A. Morley, Doug K. Allen, Gerta Hoxhaj   +8 more
openalex   +1 more source

Lipoic acid salvage enzymes differentially stimulate bacterial growth and lipoylation in a growth condition-dependent manner.

, 2016
Azul Zorzoli, Grayczyk James P., Alonzo Francis   +2 more
openalex   +1 more source

Investigating the chemistry of lipoyl synthase

, 2008
The radical SAM protein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group. Using an in vitro assay which makes use of a small peptide mimic of the protein substrate, it has now been shown at which carbon centre sulfur insertion first occurs ...
openaire   +1 more source

Cuproptosis and Cardiovascular Diseases: Mechanisms, Pathophysiology, and Therapeutic Strategies-A Narrative Review. [PDF]

Rev Cardiovasc Med
Wang Z, Wu C, Li R, Sun H, Li M, Luo Y, Bao S, Peng Y.   +7 more
europepmc   +1 more source

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis

Jeffrey C. Hsiao, Douglas M. Warui, Jason J. Kwon, Margaret Dreishpoon, Nolan Bick, Tamra C. Blue, David E. Root, Squire J. Booker, Peter Tsvetkov   +8 more
openalex   +1 more source

Charge Transfer Complexes of Lipoyl Dehydrogenase and Free Flavins [PDF]

Journal of Biological Chemistry, 1962
Graham Palmer, V. Massey
openaire   +2 more sources

Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer [PDF]

, 2018
Felipe Paredes, Kely L. Sheldon, Bernard Lassègue, Holly C. Williams, Elizabeth A. Faidley, Gloria A. Benavides, Gloria Torres, Fernanda Sanhueza‐Olivares, Samantha M. Yeligar, Kathy K. Griendling, Victor Darley‐Usmar, Alejandra San Martín   +11 more
openalex   +1 more source

Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism. [PDF]

Cell Chem Biol
Wedan RJ, Nowinski SM.
europepmc   +1 more source

p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation. [PDF]

Front Oncol
Liu X, Qu H, Li J, Sun X, Wang Z, Wang D, Bai X, Li X.   +7 more
europepmc   +1 more source