Lipoyl-E2-PDH Gets a Second Job [PDF]
Cell Host & Microbe, 2017 Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.
Michael Otto, Seth W. Dickey
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Targeted next generation sequencing in patients with inborn errors of metabolism [PDF]
, 2018 BACKGROUND: Next-generation sequencing (NGS) technology has allowed the promotion of genetic diagnosis and are becoming increasingly inexpensive and faster.
Armstrong i Morón, Judith +9 more
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Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes
mBio, 2017 Lipoic acid is an essential metabolic cofactor added as a posttranslational modification on several multimeric enzyme complexes. These protein complexes, evolutionarily conserved from bacteria to humans, are core regulators of cellular metabolism.
Elizabeth A. Rowland +5 more
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Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer
Journal of Experimental & Clinical Cancer Research, 2023 Introduction Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.
Weikai Wang +7 more
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Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae [PDF]
, 2016 Schematic diagrams of inserts within the fliDCAZ loci of FGI−/FMI− Enterobacteriaceae. Flanking genes are indicated by yellow arrows, predicted phage genes by blue arrows, fimbrial biogenesis genes by grey arrows and sugar/amino acid transporter genes by
Don A. Cowan, Pieter De Maayer
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Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
Cell Reports, 2019 Summary: Inborn errors of metabolism (IEMs) link metabolic defects to human phenotypes. Modern genomics has accelerated IEM discovery, but assessing the impact of genomic variants is still challenging.
Min Ni +22 more
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Isolation of the Cadmium Derivative of Lipoyl Dehydrogenase
Journal of Biological Chemistry, 1971 Abstract Reduced lipoamide dehydrogenase reacts with cadmium ion to form a moderately stable compound characterized by 1 g atom of cadmium bound per mole of flavin adenine dinucleotide, a modified spectrum in the visible region, and altered reactivity with electron acceptor substrates.
Jeanne H. Stein, Abraham M. Stein
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Defining Caenorhabditis elegans as a model system to investigate lipoic acid metabolism [PDF]
, 2020 Lipoic acid (LA) is a sulfur-containing cofactor that covalently binds to a variety of cognate enzymes that are essential for redox reactions in all three domains of life.
de Mendoza, Diego +2 more
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Crystal structure of lipoate‐bound lipoate ligase 1, LipL1, from Plasmodium falciparum [PDF]
, 2017 Plasmodium falciparum lipoate protein ligase 1 (PfLipL1) is an ATP‐dependent ligase that belongs to the biotin/lipoate A/B protein ligase family (PFAM PF03099).
Afanador, Gustavo A. +2 more
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Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma
Frontiers in Oncology, 2022 Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death.
Qin Hu +7 more
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