Results 71 to 80 of about 3,490 (194)
Advanced Science, Volume 12, Issue 36, September 25, 2025.This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu +8 more
wiley +1 more source
Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy
Small, Volume 21, Issue 36, September 11, 2025.Sono‐activatable TPEN‐encapsulated cancer‐targeted nanoparticles (STCNs) with sonodynamic therapy (SDT)‐amplified immunotherapeutic properties for liver cancer treatment via endogenous cuproptosis are developed. STCNs can effectively treat liver cancer through endogenous cuproptosis by TPEN and ROS generated by SDT, resulting in increased immune ...
Tianao Xie +15 more
wiley +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, Volume 5, Issue 9, September 2025.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology, Volume 9, Issue 8, August 2025.The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang +5 more
wiley +1 more source
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells [PDF]
, 2023 Pallavi R. Joshi +4 more
openalex +1 more source
Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana
Metabolites, 2019 Plant de novo fatty acid synthesis takes place in the plastid using acetyl-coenzyme A (acetyl-CoA) as the main precursor. This first intermediate is produced from pyruvate through the action of the plastidial pyruvate dehydrogenase complex (PDH), which ...
Raquel Martins-Noguerol +8 more
doaj +1 more source
Frontiers in Cell and Developmental BiologyBackgroundColon adenocarcinoma (COAD) remains a major global health challenge with poor prognosis despite advances in treatment, underscoring the need for new biomarkers. As a novel mode of cell death, cuproptosis is thought to be potentially involved in
Zhanhui Ye +10 more
doaj +1 more source
Lipoyltransferase 1 Gene Defect Resulting in Fatal Lactic Acidosis in Two Siblings
Case Reports in Obstetrics and Gynecology, 2016 A term male neonate developed severe intractable lactic acidosis on day of life 1 and died the same day at our institution. The family previously lost another term, female newborn on day of life 1 from suspected sepsis at an outside hospital.
Véronique Taché +6 more
doaj +1 more source
Copper-induced cell death mechanisms and their role in the tumor microenvironment
Frontiers in Cell DeathCopper is an essential cofactor for all organisms. However, it can become toxic if its concentration rises above a specific level. This level is controlled by evolutionary conserved homeostatic mechanisms.
Yujuan Jiao +7 more
doaj +1 more source