Results 71 to 80 of about 4,213 (194)

Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice [PDF]

open access: yes, 2019
There has been a growing interest toward mitochondrial fatty acid synthesis (mtFAS) since the recent discovery of a neurodegenerative human disorder termed MEPAN (mitochondrial enoyl reductase protein associated neurodegeneration), which is caused by ...
Autio, Kaija J.   +9 more
core   +1 more source

Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy

open access: yesSmall, Volume 21, Issue 36, September 11, 2025.
Sono‐activatable TPEN‐encapsulated cancer‐targeted nanoparticles (STCNs) with sonodynamic therapy (SDT)‐amplified immunotherapeutic properties for liver cancer treatment via endogenous cuproptosis are developed. STCNs can effectively treat liver cancer through endogenous cuproptosis by TPEN and ROS generated by SDT, resulting in increased immune ...
Tianao Xie   +15 more
wiley   +1 more source

Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function [PDF]

open access: yes, 2019
Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS ...
Autio, Kaija J.   +4 more
core   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

open access: yesSmall Science, Volume 5, Issue 9, September 2025.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong   +4 more
wiley   +1 more source

Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex [PDF]

open access: yes, 2007
The human pyruvate dehydrogenase multi-enzyme complex (PDC) catalyses the oxidative decarboxylation of pyruvate, transferring the resultant acetyl group to coenzyme A.
Al-Amodi, Hiba Saeed Bagader
core   +1 more source

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions [PDF]

open access: hybrid, 2016
Stephen P. Burr   +10 more
openalex   +1 more source

Lipoylating and biotinylating enzymes contain a homologous catalytic module [PDF]

open access: yesProtein Science, 2000
AbstractBiotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl‐ and lipoyl‐dependent enzymes is post‐translationally catalyzed by specific biotinylating and lipoylating protein enzymes.
openaire   +4 more sources

Mutations in the lipoyltransferaseLIPT1gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes [PDF]

open access: bronze, 2013
Frederic Tort   +14 more
openalex   +1 more source

Genetic dissection of the mitochondrial lipoylation pathway in yeast [PDF]

open access: gold, 2020
Laura P. Pietikäinen   +4 more
openalex   +1 more source

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