Expression and lipoylation in Escherichia coli of the inner lipoyl domain of the E2 component of the human pyruvate dehydrogenase complex [PDF]
, 1993 Janet Quinn +5 more
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Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice [PDF]
, 2019 There has been a growing interest toward mitochondrial fatty acid synthesis (mtFAS) since the recent discovery of a neurodegenerative human disorder termed MEPAN (mitochondrial enoyl reductase protein associated neurodegeneration), which is caused by ...
Autio, Kaija J. +9 more
core +1 more source
Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy
Small, Volume 21, Issue 36, September 11, 2025.Sono‐activatable TPEN‐encapsulated cancer‐targeted nanoparticles (STCNs) with sonodynamic therapy (SDT)‐amplified immunotherapeutic properties for liver cancer treatment via endogenous cuproptosis are developed. STCNs can effectively treat liver cancer through endogenous cuproptosis by TPEN and ROS generated by SDT, resulting in increased immune ...
Tianao Xie +15 more
wiley +1 more source
Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function [PDF]
, 2019 Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS ...
Autio, Kaija J. +4 more
core +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, Volume 5, Issue 9, September 2025.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex [PDF]
, 2007 The human pyruvate dehydrogenase multi-enzyme complex (PDC) catalyses the oxidative decarboxylation of pyruvate, transferring the resultant acetyl group to coenzyme A.
Al-Amodi, Hiba Saeed Bagader
core +1 more source
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions [PDF]
, 2016 Stephen P. Burr +10 more
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Lipoylating and biotinylating enzymes contain a homologous catalytic module [PDF]
Protein Science, 2000 AbstractBiotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl‐ and lipoyl‐dependent enzymes is post‐translationally catalyzed by specific biotinylating and lipoylating protein enzymes.
openaire +4 more sources
Mutations in the lipoyltransferaseLIPT1gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes [PDF]
, 2013 Frederic Tort +14 more
openalex +1 more source
Genetic dissection of the mitochondrial lipoylation pathway in yeast [PDF]
, 2020 Laura P. Pietikäinen +4 more
openalex +1 more source