Results 71 to 80 of about 4,273 (194)

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred

Protein Science, Volume 35, Issue 2, February 2026.
Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão   +2 more
wiley   +1 more source

Lipoylation of Acyltransferase Components of α-Ketoacid Dehydrogenase Complexes [PDF]

Journal of Biological Chemistry, 1996
Lipoic acid is a prosthetic group of the acyltransferase components of the pyruvate, alpha-ketoglutarate, and branched chain alpha-ketoacid dehydrogenase complexes, protein X of the eukaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system.
K, Fujiwara, K, Okamura-Ikeda, Y, Motokawa   +2 more
openaire   +2 more sources

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures, Volume 7, Issue 1, January 2026.
Chirality‐directed strategy designed by copper‐based nanoregulator (Cu‐D‐Car@HA) to potentiate collaborative cuproptosis‐immunotherapy by overcoming tumor resistance to cuproptosis highlights a materials‐based method for superior cuproptosis‐immunotherapy.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
wiley   +1 more source

Lipoylation Mechanism of P. Falciparum Mitochondrial Proteins [PDF]

Biophysical Journal, 2015
Lipoate is an essential cofactor for the aerobic metabolism in oxidative decarboxylation reactions of 2-oxoacid complexes. Malaria parasite survival is highly dependent on scavenging this essential cofactor from the human host. Scavenged lipoate is subsequently attached to the α-ketoglutarate dehydrogenase (KDH), the branched chain α-ketoacid ...
Guerra, Alfredo J., Afandor, Gustavo A., Swift, Russell P., Prigge, Sean T.   +3 more
openaire   +1 more source

Progress of Programmed Cell Death in Steroid‐Induced Osteonecrosis of the Femoral Head

Orthopaedic Surgery, Volume 18, Issue 1, Page 16-30, January 2026.
Steroid‐induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses.
Zhi Kong, Chao Han
wiley   +1 more source

Cuproptosis at the Crossroads of Tumor Microenvironment Inflammation and Metabolic Rewiring Mechanisms and Therapeutic Opportunities

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Metabolic reorganization and chronic inflammation are dynamic and diverse events in the tumor microenvironment (TME) that cause tumor propagation, spreading, and resistance to treatment. However, copper‐induced cell death (cuproptosis), which is a newly discovered form of regulated cell death (RCD) induced by high intracellular copper ions and is a ...
Yan Wang, Yunfei Zhu, Yanxin Wang, Yutong Liu, Pengfei Wang, Mingkun Yu, Hengrui Liu   +6 more
wiley   +1 more source

Mitochondrial Fatty Acids and Neurodegenerative Disorders [PDF]

, 2020
Fatty acids in mitochondria, in sensu stricto, arise either as β-oxidation substrates imported via the carnitine shuttle or through de novo synthesis by the mitochondrial fatty acid synthesis (mtFAS) pathway. Defects in mtFAS or processes involved in the
Autio, Kaija J., Kastaniotis, Alexander J., Nair, Remya R.   +2 more
core   +1 more source

Mendelian Randomization Identified SLC2A9 as a Novel cis‐eQTL‐Mediated Susceptibility Gene in Suppressing Renal Cancer and Its Related Metabolic Mechanisms

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Objective Mendelian randomization (MR) analysis has currently been widely used in combination with expression quantitative trait loci (eQTLs) or cis‐eQTLs for identifying novel drug targets in various diseases. Hence in this article, we first integrated MR analysis with eQTLs and cis‐eQTLs to reveal the causal effects among SLC2A9 and renal cancer (RC),
Yi Wang, Yu Song, Hao Ji, Bingye Zhu, Huyang Xie, Fumio Tsuji   +5 more
wiley   +1 more source

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex

Nature Communications, 2020
2-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial ...
Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan   +8 more
doaj   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source