Results 71 to 80 of about 3,490 (194)

A Mitochondria‐Targeted Nanozyme Platform for Multi‐Pathway Tumor Therapy via Ferroptosis and Cuproptosis Regulation

open access: yesAdvanced Science, Volume 12, Issue 36, September 25, 2025.
This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu   +8 more
wiley   +1 more source

Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy

open access: yesSmall, Volume 21, Issue 36, September 11, 2025.
Sono‐activatable TPEN‐encapsulated cancer‐targeted nanoparticles (STCNs) with sonodynamic therapy (SDT)‐amplified immunotherapeutic properties for liver cancer treatment via endogenous cuproptosis are developed. STCNs can effectively treat liver cancer through endogenous cuproptosis by TPEN and ROS generated by SDT, resulting in increased immune ...
Tianao Xie   +15 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

open access: yesSmall Science, Volume 5, Issue 9, September 2025.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong   +4 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

open access: yesAdvanced Biology, Volume 9, Issue 8, August 2025.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang   +5 more
wiley   +1 more source

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells [PDF]

open access: gold, 2023
Pallavi R. Joshi   +4 more
openalex   +1 more source

Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana

open access: yesMetabolites, 2019
Plant de novo fatty acid synthesis takes place in the plastid using acetyl-coenzyme A (acetyl-CoA) as the main precursor. This first intermediate is produced from pyruvate through the action of the plastidial pyruvate dehydrogenase complex (PDH), which ...
Raquel Martins-Noguerol   +8 more
doaj   +1 more source

Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients

open access: yesFrontiers in Cell and Developmental Biology
BackgroundColon adenocarcinoma (COAD) remains a major global health challenge with poor prognosis despite advances in treatment, underscoring the need for new biomarkers. As a novel mode of cell death, cuproptosis is thought to be potentially involved in
Zhanhui Ye   +10 more
doaj   +1 more source

Lipoyltransferase 1 Gene Defect Resulting in Fatal Lactic Acidosis in Two Siblings

open access: yesCase Reports in Obstetrics and Gynecology, 2016
A term male neonate developed severe intractable lactic acidosis on day of life 1 and died the same day at our institution. The family previously lost another term, female newborn on day of life 1 from suspected sepsis at an outside hospital.
Véronique Taché   +6 more
doaj   +1 more source

Corrigendum: Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma

open access: yesFrontiers in Medicine, 2023
Hanwen Lu   +12 more
doaj   +1 more source

Copper-induced cell death mechanisms and their role in the tumor microenvironment

open access: yesFrontiers in Cell Death
Copper is an essential cofactor for all organisms. However, it can become toxic if its concentration rises above a specific level. This level is controlled by evolutionary conserved homeostatic mechanisms.
Yujuan Jiao   +7 more
doaj   +1 more source

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