Results 81 to 90 of about 4,073 (218)
Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation. [PDF]
, 2018 Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.Wellcome 102770/Z/13/Z and 205252/Z/16/Z ...
Bailey, Peter SJ +4 more
core +1 more source
Mitochondrial Fatty Acids and Neurodegenerative Disorders [PDF]
, 2020 Fatty acids in mitochondria, in sensu stricto, arise either as β-oxidation substrates imported via the carnitine shuttle or through de novo synthesis by the mitochondrial fatty acid synthesis (mtFAS) pathway. Defects in mtFAS or processes involved in the
Autio, Kaija J. +2 more
core +1 more source
Mobility in pyruvate dehydrogenase complexes with multiple lipoyl domains [PDF]
FEBS Letters, 1993 High‐field NMR studies were carried out with genetically‐reconstructed pyruvate dehydrogenase (PDH) complexes of Escherichia coli containing from zero to nine lipoyl domains per lipoate acetyltransferase (E2p) subunit. The only significant differences between the NMR spectra were the increasing intensities of the signals derived from the lipoyl domains
Rosane S. Machado +2 more
openaire +3 more sources
Multiple molecular mechanisms cause reproductive isolation between three yeast species. [PDF]
PLoS Biology, 2010 Nuclear-mitochondrial conflict (cytonuclear incompatibility) is a specific form of Dobzhansky-Muller incompatibility previously shown to cause reproductive isolation in two yeast species.
Jui-Yu Chou +4 more
doaj +1 more source
Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management
MedComm, Volume 6, Issue 10, October 2025.Key pathogenic mechanisms in AMI. Oxidative stress and mitochondrial dysfunction induce ROS accumulation, while DAMPs‐PRRs interaction triggers inflammatory cascades. Programmed cell death pathways and epigenetic regulation collectively constitute the core components of AMI pathogenesis.
Mengmeng Zhu +5 more
wiley +1 more source
Antibiotics, 2023 The urgent need to combat antibiotic resistance and develop novel antimicrobial therapies has triggered studies on novel metal-based formulations. N-heterocyclic carbene (NHC) complexes coordinate transition metals to generate a broad range of anticancer
Magdalena Piatek +4 more
doaj +1 more source
Liver‐specific lncRNAs associated with liver cancers
FEBS Open Bio, Volume 15, Issue 9, Page 1383-1405, September 2025.Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina +3 more
wiley +1 more source
Cell Death Discovery, 2022 Esophageal carcinoma (ESCA) is a common type of cancer with high mortality. Cuproptosis is a new type of cell death and is characterized by the dependence on mitochondrial respiration and protein lipoylation.
Runmin Jiang +6 more
doaj +1 more source
Lipoylating and biotinylating enzymes contain a homologous catalytic module [PDF]
Protein Science, 2000 AbstractBiotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl‐ and lipoyl‐dependent enzymes is post‐translationally catalyzed by specific biotinylating and lipoylating protein enzymes.
openaire +5 more sources
Advanced Science, Volume 12, Issue 36, September 25, 2025.This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu +8 more
wiley +1 more source