Genetic dissection of the mitochondrial lipoylation pathway in yeast [PDF]
, 2020 Laura P. Pietikäinen +4 more
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Lipoylating and biotinylating enzymes contain a homologous catalytic module [PDF]
Protein Science, 2000 AbstractBiotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl‐ and lipoyl‐dependent enzymes is post‐translationally catalyzed by specific biotinylating and lipoylating protein enzymes.
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Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway [PDF]
, 2018 Felipe Paredes +8 more
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CellsCuproptosis is a novel cell death dependent on mitochondrial respiration and regulated by copper. While the study of it is mainly focused on tumor therapy, in the present study, two key cuproptosis-related genes, ferredoxin (FDX1) and dihydrolipoamide S ...
Yuxin Zhang +4 more
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Nature CommunicationsProteins with chemically regulatable phase separation are of great interest in the fields of biomolecular condensates and synthetic biology. Intrinsically disordered proteins (IDPs) are the dominating building blocks of biomolecular condensates which ...
Jinglei Nie +9 more
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Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy [PDF]
, 2017 Florence Habarou +31 more
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The Fe-S cluster assembly factors NFU4 and NFU5 are primarily required for protein lipoylation in mitochondria [PDF]
, 2021 Jonathan Przybyla‐Toscano +7 more
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Investigating the chemistry of lipoyl synthase
, 2008 The radical SAM protein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group. Using an in vitro assay which makes use of a small peptide mimic of the protein substrate, it has now been shown at which carbon centre sulfur insertion first occurs ...
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Ferredoxin 1 is essential for embryonic development and lipid homeostasis
eLifeMammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways ...
Shakur Mohibi +5 more
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Research progress on the regulation of cuproptosis-related genes by non-coding RNAs in tumors
OncologieCuproptosis represents a mechanistically distinct programmed cell death pathway divergent from canonical apoptosis, necrosis, and ferroptosis. This copper-dependent process critically modulates tumorigenesis, malignant progression, and clinical outcomes ...
Du Yuxin +4 more
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