Results 51 to 60 of about 659,295 (264)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Automated processing of whole blood samples for the determination of immunosuppressants by liquid chromatography tandem-mass spectrometry [PDF]
, 2006 Background: Liquid chromatography tandem-mass spectrometry (LC-MS/MS) is an efficient technology for routine determination of immunosuppressants in whole blood; however, time-consuming manual sample preparation remains a significant limitation of this ...
Spöhrer, Ute, Vogeser, Michael
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Extraction of Diterpenoid Lactones of Andrographis paniculata using Liquid Solvents: Effect of Solvent’s Hildebrand Solubility Parameter on Extraction Efficiency [PDF]
, 2006 Two diterpenoid lactones responsible to the multi healing properties of Andrographis paniculata have been extracted using 16 different liquid solvents. The effect of Hildebrand solubility parameter of the solvents on solid-liquid extraction yield using ...
Kumoro, A.C., Hasan, M.
core
, 2015 Enrichment and recovery of valuable components in industrial waste waters by traditional liquid-liquid solvent extraction is not economic due to extremely low concentrations of those targets. Large-phase-ratio extraction exhibits potential advantages for
Liu, Jie +3 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2011 In recent years, hollow fiber based liquid-liquid-liquid micro-extraction (HF-LLLME) [1] has been widely studied due to its higher enrichment factor, excellent ability of clean-up, and lower consumption of organic solvent.
沈铮, 关亚风, 吴倩, 吴大朋
core +1 more source
BMC Chemistry, 2019 In this study, a simple one-step ionic liquid-based ultrasound-assisted dispersive liquid–liquid microextraction technique was coupled with high-performance liquid chromatography for the analysis of four pyrethroids in three kinds of traditional Chinese ...
Yiyi Liao +8 more
doaj +1 more source
Liquid–liquid extraction: thermodynamics–kinetics driven processes explored by microfluidics
Comptes Rendus. Chimie, 2022 Liquid–liquid extraction processes, characterized on-line by instrumented microfluidic platform, significantly enhance the development of predictive thermodynamic models, such as ienaics, and lay the foundations for new approaches to improve kinetic ...
Olivier, Fabien +3 more
doaj +1 more source
Solid–liquid transport in a modified co-rotating twin-screw extruder-dynamic simulator and experimental validations [PDF]
, 2004 This work presents a dynamic transport model of a solid–liquid media through a twin-screw extruder (TSE). The application under consideration is the solid–liquid extraction of solute from raw plant substrate.
Prat, Laurent E. +4 more
core +1 more source