Results 231 to 240 of about 126,740 (294)

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat   +6 more
wiley   +1 more source

Comparison of Tissue Preparations to Identify and Phenotype T Cells in Human Colorectal Tumor Tissue

open access: yesCytometry Part A, EarlyView.
ABSTRACT Archived patient samples (e.g., formalin‐fixed paraffin embedded (FFPE) tissue blocks, cryoembedded tissue blocks, and frozen whole tissue samples) are a source of immune information for which corresponding patient data is often collected.
Justin F. Tirados   +5 more
wiley   +1 more source

From concept to clinic: emerging paradigms and novel insights into liquid biopsy. [PDF]

open access: yesCancer Biol Med
Guo W   +7 more
europepmc   +1 more source

Extended High‐Risk HPV Genotyping With BD Onclarity Enhances Anal Cancer Screening Among High‐Risk Populations: A Cross‐Sectional Study

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Background Anal cancer rates are rising among women, immunocompromised individuals, and Men who have sex with Men (MSM), independent of HIV status. While high‐resolution anoscopy remains the diagnostic standard, limited access has increased interest in alternative screening.
Daisy Maharjan   +5 more
wiley   +1 more source

Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen—A Case Report and Literature Review

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
William H. Wu   +2 more
wiley   +1 more source

Editorial: Mechanisms of metastasis from circulating and disseminated tumor cells

open access: yesFrontiers in Cell and Developmental Biology
Roberto Piñeiro, Roberto Piñeiro
doaj   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick   +3 more
wiley   +1 more source

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