Results 61 to 70 of about 175,341 (310)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Computer simulations of liquid crystals [PDF]
, 2000 Molecular simulations performed on modern computers provide a powerful tool for the investigation of both static and dynamic properties of liquid crystals. In this thesis several properties of liquid crystal mesogens have been investigated using state-of-
Cook, Melanie Joanna
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Nano-Objects and Ions in Liquid Crystals: Ion Trapping Effect and Related Phenomena
Crystals, 2015 The presence of ions in liquid crystals is one of the grand challenges that hinder the application of liquid crystals in various devices, which include advanced 3-D and flexible displays, tunable lenses, etc.
Yuriy Garbovskiy, Iryna Glushchenko
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide
Drug Delivery, 2019 The purpose of this study was to develop and evaluate triptolide-loaded cubic and hexagonal liquid crystals for transdermal drug delivery systems (TDDSs).
Qian-Qian Shan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
JPhys PhotonicsFerroelectric thin films integrated on passive photonic platforms offer ways to achieve functionalities that are otherwise impossible or inefficient, such as electro-optic (EO) modulation, acousto-optic modulation or optical nonlinear conversion ...
Kobe De Geest +5 more
doaj +1 more source
Flüssigkristalle und ihre Anwendungen
CHIMIA, 1977 Liquid Crystals are Compounds whose molecules assume an order which lie intermediate between the almost perfect long-range order found in solid crystals and the statistical long-range disorder of an isotropic liquid.
Maged A. Osman
doaj +1 more source