Results 31 to 40 of about 343,439 (265)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Plasticized Ionic Liquid Crystal Elastomer Emulsion-Based Polymer Electrolyte for Lithium-Ion Batteries

Batteries
The development and electrochemical characteristics of ionic liquid crystal elastomers (iLCEs) are described for use as electrolyte components in lithium-ion batteries.
Zakaria Siddiquee, Hyunsang Lee, Weinan Xu, Thein Kyu, Antal Jákli   +4 more
doaj   +1 more source

Mathematical Modeling of Recursive Drug Delivery with Diffusion, Equilibrium, and Convection Coupling

Mathematics, 2022
In this work, a mathematical model to describe drug delivery from polymer coatings on implants is proposed. Release predictability is useful for development and understanding of drug release mechanisms from controlled delivery systems. The proposed model
Rosaura Hernandez-Montelongo, Javiera Salazar-Araya, Jacobo Hernandez-Montelongo, Juan Paulo Garcia-Sandoval   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Synthesis of electro-optically active polymer composite of poly[2,2'-bis(3,4-ethylenedioxythiophene)-alt-fluorene]/hydroxypropyl cellulose showing liquid crystal structure

eXPRESS Polymer Letters, 2017
Electrochemical preparation of a composite consisting of poly[2,2′-bis(3,4-ethylenedioxythiophene)-alt-fluorene] and hydroxypropyl cellulose (PEFE/HPC) was carried out.
N. Eguchi, K. Kawabata, H. Goto
doaj   +1 more source

A Photomechanical Film in which Liquid Crystal Design Shifts the Absorption into the Visible Light Range

Advanced Science, 2023
Liquid crystalline polymer networks (LCN) with azobenzene monomers bend reversibly under UV‐light irradiation, combining photomechanical and photothermal effects.
Sven Schultzke, Nikolai Scheuring, Pim Puylaert, Matthias Lehmann, Anne Staubitz   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Hybrid polymer electrolyte for Li–O2 batteries

Green Energy & Environment, 2019
Li–O2 batteries have attracted much attention because of their high specific energy. However, safety problem generated mainly from the flammable organic liquid electrolytes have hindered the commercial use of Li–O2 batteries.
Bojie Li, Yijie Liu, Xiaoyu Zhang, Ping He, Haoshen Zhou   +4 more
doaj   +1 more source