Results 21 to 30 of about 11,022 (215)

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

Labyrinthine Turing Pattern Formation in the Cerebral Cortex [PDF]

, 2002
I propose that the labyrinthine patterns of the cortices of mammalian brains may be formed by a Turing instability of interacting axonal guidance species acting together with the mechanical strain imposed by the interconnecting axons.Comment: See home ...
BAIER, BARD, CARTWRIGHT, CASTETS, DICKSTEIN, DOBYNS, ERNST, FITZHUGH, FITZHUGH, GOLDSTEIN, GOODHILL, GOODWIN, GRIFFIN, HENTSCHEL, JUDD, JULYAN H.E. CARTWRIGHT, KAUFFMAN, KOCH, KONDO, MEINHARDT, MURATOV, MURRAY, MURRAY, NAGUMO, ODELL, OSTER, OUYANG, RAGHAVAN, RAKIC, RAMÓN Y CAJAL, RICHMAN, SCANNELL, SEUL, TESSIER-LAVIGNE, TODD, TURING, VAN DER POL, VAN ESSEN, WATZL, WITELSON, ZHENG, ZILLES   +41 more
core   +3 more sources

A developmental and genetic classification for malformations of cortical development: update 2012. [PDF]

, 2012
Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain
Barkovich, A James, Dobyns, William B, Guerrini, Renzo, Jackson, Graeme D, Kuzniecky, Ruben I   +4 more
core   +3 more sources

Perampanel in lissencephaly-associated epilepsy

Epilepsy and Behavior Case Reports, 2019
We retrospectively investigated whether perampanel (PER) could serve as an alternative for treating drug-resistant seizures in lissencephaly. We investigated the following data: age at onset of epilepsy, age at start of PER, etiology, brain MRI findings,
Satoru Ikemoto, Shin-ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Reiko Koichihara   +4 more
doaj   +1 more source

A de novo microdeletion involving PAFAH1B (LIS1) related to lissencephaly phenotype

Data in Brief, 2015
Lissencephaly is a type of the congenital malformation of the brain. Due to the impairments of neuronal migration, patients show absence of brain convolution manifesting smooth brain surfaces.
Keiko Shimojima, Akihisa Okumura, Toshiyuki Yamamoto   +2 more
doaj   +1 more source

Dictyostelium discoideum: A Model System for Neurological Disorders

Cells, 2022
Background: The incidence of neurological disorders is increasing due to population growth and extended life expectancy. Despite advances in the understanding of these disorders, curative strategies for treatment have not yet eventuated. In part, this is
Claire Louise Storey, Robin Simon Brooke Williams, Paul Robert Fisher, Sarah Jane Annesley   +3 more
doaj   +1 more source

Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε)

Brain Sciences, 2021
The 17p13.3 chromosome region is often deleted or duplicated in humans, resulting in severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13.3 duplication syndrome.
Xiaonan Liu, Sarah A. Bennison, Lozen Robinson, Kazuhito Toyo-oka   +3 more
doaj   +1 more source

Dandy-Walker malformation: is the "tail sign" the key sign? [PDF]

, 2015
OBJECTIVE.To demonstrate the value of the "tail sign" in the assessment of Dandy-Walker Malformation (DWM). METHODS: A total of 31fetal MRI, performed before 24 weeks of gestation after second-line US examination between May 2013 and September 2014 ...
Aliberti, C, Bernardo, Silvia, Giancotti, Antonella, Manganaro, Lucia, Porpora, Maria Grazia, Rizzo, G, Saldari, Matteo, Servadei, F, Silvestri, E, Triulzi, F, Vinci, Valeria   +10 more
core   +1 more source

Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window? [PDF]

, 2016
LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGEmyd mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular ...
A Brancaccio, A von Renesse, A Yoshida, AK Marrone, AM Beedle, AS Pawlisz, Atsushi Asakura, B Constantin, C Whitmore, CJ Moore, D Beltran-Valero de Bernabe, D. J. Wells, DE Michele, DJ Lefeber, E. Lacey, EL McDearmon, F Saito, H. Booler, J Liu, J van Reeuwijk, J. C. W. Hildyard, JM Ervasti, JS Satz, K Kobayashi, K Koehler, KG Meilleur, KJ Carss, KM Wright, LT Guo, M Bozzi, M Brockington, M Kanagawa, M Ogawa, M. Hopkinson, MD Henry, MD Henry, MM Goddeeris, MR Ackroyd, MR Ackroyd, MT Garcia-Silva, O Ibraghimov-Beskrovnaya, O Thompson, P Zhang, PJ Holzfeind, PK Grewal, R Barone, R Barresi, R Shaheen, S Sugita, S Vuillaumier-Barrot, S. C. Brown, T Roscioli, T Toda, T Willer, Y Omori   +54 more
core   +9 more sources

Dysregulation of mTOR signalling is a converging mechanism in lissencephaly [PDF]

Nature
Nenad Sestan, Murat Günel, Ce Zhang
exaly   +2 more sources