Results 81 to 90 of about 7,495 (203)

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly [PDF]

, 2008
Mutations in the α-1a Tubulin (TUBA1A) gene have recently been found to cause cortical malformations resemblant of classical lissencephaly but with a specific combination of features.
Martin, P., van der Knaap, M.S., Lachmeijer, A.M.A., Lachmeijer, AMA, Omran, H, Martins, M., Zeschnigk, C., Kuechler, A., Schuierer, G, Haug, V., Morris-Rosendahl, D. J., Uyanik, G., Omran, H., Zeschnigk, C, Kutsche, K, Kraus, U., van der Knaap, M. S., Morris‐Rosendahl, DJ, Morris-Rosendahl, D.J., Najm, J., Kraus, U, Kuechler, A, Santos, M., Schuierer, G., Van der Knaap, MS, Sztriha, L., Martins, M, Vasconcelos, C, Kutsche, K., Haug, V, Uyanik, G, Lachmeijer, A. M. A., Santos, M, Vasconcelos, C., Najm, J, Sztriha, L, Martin, P   +36 more
core   +1 more source

Dysregulation of mTOR signalling is a converging mechanism in lissencephaly. [PDF]

Cerebral cortex development in humans is a highly complex and orchestrated process that is under tight genetic regulation. Rare mutations that alter gene expression or function can disrupt the structure of the cerebral cortex, resulting in a range of ...
Mane, Shrikant, Kaymakcalan, Hande, Narayanan, Anand, Sestan, Nenad, Koroglu, Merve Nur, Ercan-Sencicek, A. Gulhan, Caglar, Caner, Wang, Guilin, Takeo, Yutaka, Lopez-Giraldez, Francesc, Cortes, Joelly, Bulut, Aybike S., Yalcinkaya, Cengiz, Nishimura, Sayoko, Barak, Tanyeri, Yasuno, Katsuhito, Liang, Dan, Tuysuz, Beyhan, Lam, TuKiet T., Guzel, Aslan, Miyagishima, Danielle F., Henegariu, Octavian, Wang, Xinyuan, Mishra-Gorur, Ketu, Erson-Omay, E. Zeynep, Peksen, A. Buket, Louvi, Angeliki, Bilguvar, Kaya, Zhang, Ce, Caglayan, AHMET OKAY, Gunel, Murat, Cheng, Iris Q.   +31 more
core   +1 more source

Electrographic Changes Accompanying Recurrent Seizures under Ketogenic Diet Treatment

Pharmaceuticals, 2017
The ketogenic diet (KD) is increasingly used to treat epilepsy refractory to antiepileptic drugs and other neurological disorders. In animal models, the KD was found to increase the threshold to seizures induced by different convulsive stimulations ...
Chiara Lucchi, Maddalena Marchiò, Elisa Caramaschi, Carmela Giordano, Rocco Giordano, Azzurra Guerra, Giuseppe Biagini   +6 more
doaj   +1 more source

Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly

eLife, 2020
Type I lissencephaly is a neuronal migration disorder caused by haploinsuffiency of the PAFAH1B1 (mouse: Pafah1b1) gene and is characterized by brain malformation, developmental delays, and epilepsy.
Tyler G Ekins, Vivek Mahadevan, Yajun Zhang, James A D'Amour, Gülcan Akgül, Timothy J Petros, Chris J McBain   +6 more
doaj   +1 more source

Clinical features of 21 patients with lissencephaly type I (agyria-pachygyria)

The Turkish Journal of Pediatrics, 2000
Lissencephaly (agyria-pachygyria) is the most severe neuronal migration disorder, characterized by total or partial absence of gyri. In this study, 21 patients with lissencephaly type I (9 girls, 12 boys) with a mean age of 19 +/- 21 months (2 ...
M Ozmen, Y Yilmaz, M Calişkan, O Minareci, N Aydinli   +4 more
doaj  

Lizensefali Tip 1'in eşlik ettiği dikkat eksikliği ve hiperaktivite bozukluğu

Sakarya Tıp Dergisi, 2012
Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) dikkatsizlik, dikkat dağınıklığı, yerinde duramama,aşırı hareketlilik, dürtüsellik ile karakterizedir. DEHB'de beyinde yapısal ve fonksiyonel değişikliklerin olduğuna dair kanıtlar vardır.
Dilcan Kotan, İsmet Kırpınar, Tülin Fidan   +2 more
doaj   +1 more source

Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation

eLife, 2020
Layering has been a long-appreciated feature of higher order mammalian brain structures but the extent to which it plays an instructive role in synaptic specification remains unknown.
James A D'Amour, Tyler Ekins, Stuti Ganatra, Xiaoqing Yuan, Chris J McBain   +4 more
doaj   +1 more source

LIS1-Related Isolated Lissencephaly: Spectrum of Mutations and Relationships With Malformation Severity [PDF]

, 2009
International audienceObjective: With the largest data set of patients with LIS1-related lissencephaly, the major cause of posteriorly predominant lissencephaly related to either LIS1 mutation or intragenic deletion, described so far, we aimed to refine ...
Des Portes, Vincent, Pitelet, Gaëlle, Barthez, Marie Anne, Quelin, Chloe, Saillour, Yoann, Mercier, Sandra, Joriot, Sylvie, Carion, Nathalie, Philip, Nicole, Cances, Claude, Broglin, Dominique, Moutard, Marie Laure, Kaminska, Anna, Toutain, Annick, Elie, Caroline, Chelly, Jamel, Beldjord, Chérif, ROUBERTIE, Agathe, Pinard, Jean-Marc, Bahi-Buisson, Nadia, Milh, Mathieu, Cancès, Clément, Leger, Pierre-Louis, Boddaert, Nathalie   +23 more
core   +1 more source

Total callosotomy ameliorates epileptic activity and improves cognitive function in a patient with Miller-Dieker syndrome

Epilepsy & Behavior Reports
Miller-Dieker syndrome (MDS) is characterized by facial abnormalities and lissencephaly and is caused by a microdeletion in the region containing the LIS1 gene at chromosome 17p13.3.
Masataka Fukuoka, Ichiro Kuki, Yuka Hattori, Hitomi Tsuji, Asako Horino, Megumi Nukui, Takeshi Inoue, Shin Okazaki, Noritsugu Kunihiro, Takehiro Uda   +9 more
doaj   +1 more source