Results 41 to 50 of about 14,653 (265)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
“The case” of Poor Ioanide, or on critical reception in different stages of post-war Romanian literary history [PDF]
Diversitate si Identitate Culturala in EuropaThis article aims to present some aspects regarding the critical reception of the novel Bietul Ioanide, whose subject is set in the post-war period.
Ana-Maria BĂNICĂ
doaj
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The Material and “Inner Life” in Music: Beethoven, Psychological Coherence, and Meaning
Humanities, 2015 Current studies on Adolph Bernhard Marx generally focus on Marx’s seminal texts in music theory and pedagogy, such as Die Lehre von der musikalischen Komposition, praktisch theoretisch (1837–1847) and Marx’s theory of sonata form, but they infrequently ...
Sara Eckerson
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A prophet in his country [PDF]
Diversitate si Identitate Culturala in Europa, 2018 This text is a tribute to the academician Eugen Simion, on his 85th birthday. A former president of the Romanian Academy (1998 – 2006), member of academic societies in France, Denmark, Moldova, university professor, literary critic and historian, editor,
Lucian CHIȘU
doaj
Mediações Dilaceradas: Linguagem e Experiência no Pensamento de Theodor Adorno
MatLit, 2013 This article focuses on the concept of "mediation" as used by Adorno throughout his philosophical and critical work. Starting with his discussion about culture in contemporary society, the paper examines his reflections on language as a process lacerated
Matheus de Brito
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Stimmungen or "In the Mood for Differentiality"
MatLit, 2014 Review of Hans Ulrich GUMBRECHT. Atmosphere, Mood, Stimmung: On a Hidden Potential of Literature, Trans. Erik Butler, Stanford, CA: Stanford University Press, 2012, pp. 148 [1st ed. Munich, Carl Hanser Verlag, 2011].
Matheus de Brito
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source