Results 41 to 50 of about 6,827,876 (298)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Romanticism and the Insistence of the Aesthetic [PDF]

open access: yes, 2005
This volume of Romantic Circles Praxis Series includes an editor's introduction by Forest Pyle, essays by Ian Balfour, David Ferris, Karen Swann, with a response by Marc Redfield.  In spite of the recent prevalence of historical and sociological ...
Romantic Circles
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Secularism, Cosmopolitanism, and Romanticism [PDF]

open access: yes, 2008
This volume of Romantic Circles Praxis Series includes an editor's introduction by Colin Jager, essays by Mark Canuel, Colin Jager, Paul Hamilton, and Bruce Robbins.  This volume begins to unpack the relationships among the three terms of its title.
Romantic Circles
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Romanticism and Contemporary Poetry and Poetics [PDF]

open access: yes, 2003
This volume of Romantic Circles Praxis Series includes an editor's introduction by Lisa M. Steinman, essays by Charles Altieri, Robert Kaufman, and Ellen Keck Stauder.  In this volume, three divergent critics--representing Romanticism, contemporary ...
Romantic Circles
core   +1 more source

Detecting Crop Circles in Google Earth Images with Mask R-CNN and YOLOv3

open access: yesApplied Sciences, 2021
Automatic detection and counting of crop circles in the desert can be of great use for large-scale farming as it enables easy and timely management of the farming land.
Mohamed Lamine Mekhalfi   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Drawing Euler Diagrams with Circles [PDF]

open access: yes, 2010
Euler diagrams are a popular and intuitive visualization tool which are used in a wide variety of application areas, including biological and medical data analysis.
Howse, John   +7 more
core   +1 more source

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