Results 71 to 80 of about 6,827,876 (298)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Integrating Literature Circles Strategy (LCs) into Bilingual Curricula: A Pathway to Enhanced Writing and Storytelling Performance Skills in the Egyptian Japanese Schools [PDF]

مجلة العلوم التربوية بکلية التربية، جامعة الغردقة
This study examined the effectiveness of an LCs based program in developing writing and storytelling skills among primary-stage pupils at the Egyptian Japanese school. The program attempted to address the potential benefits of a student-centered approach
Lamia Mohamed Abd El Aty, Haggag Mohamed Haggag, Asmaa Ghanem Ghaith, Mohamed Salah Mohamed   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Using Mathematics Literature with Prospective Secondary Mathematics Teachers

Journal of Mathematics Education at Teachers College, 2014
Literature in mathematics has been found to foster positive improvements in mathematics learning. This manuscript reports on a mathematics teacher educator’s use of literature via literature circles with 11 prospective secondary mathematics teachers in a
Christopher C. Jett
doaj   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Quality circles for quality improvement in primary health care: Their origins, spread, effectiveness and lacunae- A scoping review.

PLoS ONE, 2018
Quality circles or peer review groups, and similar structured small groups of 6-12 health care professionals meet regularly across Europe to reflect on and improve their standard practice.
Adrian Rohrbasser, Janet Harris, Sharon Mickan, Kali Tal, Geoff Wong   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Why the fuss over Brown’s The Da Vinci code? The dynamism of 'icons' and the in/stability of meaning

Koers : Bulletin for Christian Scholarship, 2009
Dan Brown’s book, “The Da Vinci code” (2003) and the sub-sequent motion picture by the same title (2006), have created a considerable stir within, but not limited to, Christian circles.
C. Lombaard
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Japanese instructional circles

, 2023
Hiebert, JamesThis study aims to elucidate a common professional learning opportunity in Japan, instructional circles, which has not yet been studied systematically or described in detail.
Melville, Matthew David
core   +1 more source