Results 101 to 110 of about 1,657,475 (313)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Media Pembelajaran Learning Media for Suku Anak Dalam Folklore Using the iSpring Suite Application in Inclusive Education

Journal for Lesson and Learning Studies
The limited availability of interactive learning media and the lack of integration of local wisdom have led to low student interest and ability in understanding the elements and cultural values of Suku Anak Dalam (SAD) folklore.
Rustam, Hary Soedarto Harjono, Priyanto, Lusia Oktri Wini   +3 more
doaj   +1 more source

Grey literature in Australian education

, 2013
The prevalence of informal publishing or grey literature in education appears to have increased as digital technologies have become main-stream, educators have become more proficient and policies have moved increasingly towards supporting its use.
Weldon, Paul (ACER), Galatis, Helen (ACER), Tyndall, Jessica (Flinders University), Thomas, Julian (Swinburne University), GreyNet, Grey Literature Network Service, White, Gerald (ACER), Lawrence, Amanda (Swinburne University)   +6 more
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Exploring the Ethical Dimensions of Testing and Assessment: An Investigation Into Grade Inflation Among EFL Teachers

Okara: Jurnal Bahasa dan Sastra
Concerns over grade inflation have been raised since teachers tend to give students higher grades than they should. If the level of achievement does not correspond to an appropriate improvement in quality, it can raise concerns about the value of grades ...
Enggar Pangesti Wibowo, Ayu Lestari, Merry Adrian, Kanaya Salsabila Firdausiyah, Jiaul Haque Islamiy, Raudhah Diara Putri, Taufiq Kemal, Eri Kurniawan   +7 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Exploration of symbolic meanings: a semiotic study of Kelong oral literature performance in Makassar community

Cogent Arts & Humanities
The Makassar Kelong Performance (henceforth abbreviated as MKP) is an oral literary performance presented in the wedding tradition of the Makassar community to convey moral messages.
Nursalam Nursalam, Anang Santoso, Imam Agus Basuki, Askarman Laia, Callista Buena Sinamo, Bambang Prastio   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Voices from the prairie : English teachers' relationship to prairie literature [PDF]

, 1998
vi, 109 leaves ; 28 cm. --This study is an exploration of the traditions of and the appreciation afforded prairie authorship by Alberta high school English teachers.
Chomany, Laurie, University of Lethbridge. Faculty of Education   +1 more
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